Performance evaluation of a newly developed high-resolution, dual-head animal SPECT system based on the NEMA NU1-2007 standard.
Performance evaluation of a newly developed high-resolution, dual-head animal SPECT system based on the NEMA NU1-2007 standard.
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DOI：
10.1120/jacmp.v15i6.4936
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发表时间：
2014-11-08
影响因子：
2.1
通讯作者：
Ay MR
中科院分区：
文献类型：
--
作者：
Moji V;Zeratkar N;Farahani MH;Aghamiri MR;Sajedi S;Teimourian B;Ghafarian P;Sarkar S;Ay MR
小动物单光子发射计算机断层扫描(SPECT)系统在临床前阶段的药物开发和潜在药物研究领域发挥着重要作用。小动物高分辨率SPECT(HiReSPECT)扫描仪是最近在紧凑型和高分辨率探测器的基础上设计和开发的。探测器基于高分辨率平行孔准直器、碘化铯(钠激活)像素化晶体阵列和两个H8500位置灵敏光电倍增管。在该系统中，提供了能量、线性度和均匀性等全套数据校正，以及重建算法中的分辨率恢复选项。在这项研究中，我们评估了基于NEMA-NU1-2007像素化探测器摄像机标准的系统性能。HiReSPECT的特征是通过测量包括平面和断层扫描性能在内的物理参数来执行的。用能量分辨率和均匀性的泛场体模表征了系统的平面性能。空间分辨率和灵敏度分别作为与毛细管源和圆柱源距离的函数。断层扫描的空间分辨率是旋转半径(ROR)的函数。使用专用的热棒体模和图像质量体模来评价HiReSPECT的整体层析质量。结果表明，当光源放置在探测器表面时，其平面空间分辨率分别为短轴和长轴方向的半高全宽(FWHM)。经均匀度校正后，系统在有效视场(UFOV)和中心视场(CFOV)的积分均匀度分别为1.7%和1.2%。准直器表面的系统灵敏度随距离变化很小，且变化不大。平均断层空间分辨率测量为mm×FWHM，旋转半径为25 mm，采用双头结构。测量性能表明，HiReSPECT扫描仪具有可接受的图像质量，因此非常适合于临床前分子成像研究。PAC编号：87.57.U
Small‐animal single‐photon emission computed tomography (SPECT) system plays an important role in the field of drug development and investigation of potential drugs in the preclinical phase. The small‐animal High‐Resolution SPECT (HiReSPECT) scanner has been recently designed and developed based on compact and high‐resolution detectors. The detectors are based on a high‐resolution parallel hole collimator, a cesium iodide (sodium‐activated) pixelated crystal array and two H8500 position‐sensitive photomultiplier tubes. In this system, a full set of data corrections such as energy, linearity, and uniformity, together with resolution recovery option in reconstruction algorithms, are available. In this study, we assessed the performance of the system based on NEMA‐NU1–2007 standards for pixelated detector cameras. Characterization of the HiReSPECT was performed by measurement of the physical parameters including planar and tomographic performance. The planar performance of the system was characterized with flood‐field phantom for energy resolution and uniformity. Spatial resolution and sensitivity were evaluated as functions of distance with capillary tube and cylindrical source, respectively. Tomographic spatial resolution was characterized as a function of radius of rotation (ROR). A dedicated hot rod phantom and image quality phantom was used for the evaluation of overall tomographic quality of the HiReSPECT. The results showed that the planar spatial resolution was and in terms of full‐width at half‐maximum (FWHM) along short‐ and long‐axis dimensions, respectively, when the source was placed on the detector surface. The integral uniformity of the system after uniformity correction was 1.7% and 1.2% in useful field of view (UFOV) and central field of view (CFOV), respectively. System sensitivity on the collimator surface was and didn't vary significantly with distance. Mean tomographic spatial resolution was measured mm FWHM at the radius of rotation of 25 mm with dual‐head configuration. The measured performance demonstrated that the HiReSPECT scanner has acceptable image quality and, hence, is well suited for preclinical molecular imaging research. PACS number: 87.57.U
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