Glial Regulation of the Neuronal Connectome through Local and Long-Distant Communication.

Glial Regulation of the Neuronal Connectome through Local and Long-Distant Communication.
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通过局部和长途通信对神经元连接组的神经胶质调节。

DOI:
10.1016/j.neuron.2015.01.014
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发表时间:
2015-04-22
期刊:
影响因子:
16.2
通讯作者:
Basser, Peter J.
Basser, Peter J.
中科院分区:
医学1区
文献类型:
--
作者:
Fields, R. Douglas;Woo, Dong Ho;Basser, Peter J.

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如果“连接组”代表了大脑中解剖学和功能连接的完整图谱,那么它也应该包括神经胶质。神经胶质细胞在很大的长度范围内定义和调节大脑的解剖和功能连接,从整个大脑到突触相互作用的亚细胞区域。这篇透视文章探讨了神经胶质与神经元连接组的相互作用,包括远程网络、局部电路和单个突触连接;并强调了未来研究的机会。如果不了解从单个突触到回路,所有类型的胶质细胞如何促进神经元的连接和功能,我们对神经元连接组的结构和功能的理解将是不完整的。
If “the connectome” represents a complete map of anatomical and functional connectivity in the brain, it should also include glia. Glia define and regulate both the brain’s anatomical and functional connectivity over a broad range of length scales, spanning the whole brain to subcellular domains of synaptic interactions. This Perspective article examines glial interactions with the neuronal connectome, including long-range networks, local circuits, and individual synaptic connections; and highlights opportunities for future research. Our understanding of the structure and function of the neuronal connectome would be incomplete without an understanding of how all types of glia contribute to neuronal connectivity and function, from single synapses to circuits.
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