Scaling brain size, keeping timing: evolutionary preservation of brain rhythms.

Scaling brain size, keeping timing: evolutionary preservation of brain rhythms.
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DOI:
10.1016/j.neuron.2013.10.002
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发表时间:
2013-10-30
期刊:
影响因子:
16.2
通讯作者:
Singer W
Singer W
中科院分区:
医学1区
文献类型:
--
作者:
Buzsáki G;Logothetis N;Singer W

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在哺乳动物进化过程中,尽管脑体积增加了数千倍,但脑振荡的层级结构却显著地保留了下来,这使得神经网络内部和之间能够以大致相同的速度进行多时间尺度的通信,而与脑的大小无关。长距离神经元大直径轴突的分布可能是不断增长的大脑中时间管理得以保留的一个关键因素。我们讨论了这种保留的网络结构在精神疾病、药物研发和介入治疗中的影响。
Despite the several-thousand-fold increase of brain volume during the course of mammalian evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for multiple-time-scale communication within and across neuronal networks at approximately the same speed, irrespective of brain size. Deployment of large-diameter axons of long-range neurons could be a key factor in the preserved time management in growing brains. We discuss the consequences of such preserved network constellation in mental disease, drug discovery, and interventional therapies.
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