Effect of the Probiotic Saccharomyces boulardii on Cholesterol and Lipoprotein Particles in Hypercholesterolemic Adults: A Single-Arm, Open-Label Pilot Study.
Effect of the Probiotic Saccharomyces boulardii on Cholesterol and Lipoprotein Particles in Hypercholesterolemic Adults: A Single-Arm, Open-Label Pilot Study.
复制标题
益生菌布拉氏酵母对高胆固醇血症成人胆固醇和脂蛋白颗粒的影响：单臂、开放标签试点研究。
DOI：
10.1089/acm.2014.0063
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Zwickey,Heather
中科院分区：
文献类型：
--
作者：
Ryan,JenniferJoan;Hanes,DouglasAllen;Schafer,MorganBeth;Mikolai,Jeremy;Zwickey,Heather
目的：血胆固醇水平升高是冠状动脉疾病的主要危险因素，冠状动脉疾病是世界范围内死亡的主要原因。益生菌作为潜在的降胆固醇疗法已经被研究过，但之前没有研究评估过益生菌酵母菌对人类志愿者胆固醇水平的影响。本研究的目的是检验s。高胆固醇血症成人血清胆固醇和脂蛋白颗粒的变化。设计：本研究是一项单臂、开放标签的先导研究。研究对象：12名高胆固醇患者被纳入研究；一个人退学了。干预：参与者服用5.6×1010colony成形单元（CFU）封装的ds。boulardii(酿酒cerevisiaevar。bolardiicncm I-1079)每日两次，持续8周。结果测量：空腹胆固醇浓度（总胆固醇、低密度脂蛋白-胆固醇[LDL- c]、高密度脂蛋白-胆固醇[HDL- c]和甘油三酯）、脂蛋白颗粒（极低密度脂蛋白-颗粒[VLDL-P]、残余脂蛋白颗粒[RLP-P]、总LDL- p、LDL- III-P、LDL- IV-P、总HDL- p和HDL- 2b-P），以及其他心血管生物标志物(载脂蛋白B-100、脂蛋白[a]、高敏c反应蛋白、同型半胱氨酸、纤维蛋白原、和胰岛素)分别在基线，4周和8周后测量。结果：8周内，残余脂蛋白颗粒减少15.5% （p=0.03）。其余的结果测量没有明显改变。结论：在这项初步研究中，每天补充8周s。冠状动脉疾病治疗和预防的预测性生物标志物和潜在的治疗靶点。
Objectives:Elevated blood cholesterol levels are a major risk factor for coronary artery disease, the leading cause of death worldwide. Probiotics have been investigated as potential cholesterol-lowering therapies, but no previous studies have assessed the effect of the probiotic yeastSaccharomyces boulardiion cholesterol levels in human volunteers. The objective of this study was to examine the effect ofS. boulardiion serum cholesterol and lipoprotein particles in hypercholesterolemic adults.Design:This study was a single-arm, open-label pilot study.Subjects:Twelve hypercholesterolemic participants were recruited into the study; one dropped out.Intervention:Participants took 5.6×1010colony forming unit (CFU) encapsulatedS. boulardii(Saccharomyces cerevisiaevar.boulardiiCNCM I-1079) twice daily for an 8-week period.Outcome measures:Fasting concentrations of cholesterol (total cholesterol, low-density lipoprotein-cholesterol [LDL-C], high-density lipoprotein-cholesterol [HDL-C], and triglycerides), lipoprotein particles (very-low-density lipoprotein-particle [VLDL-P], remnant lipoprotein particle [RLP-P], total LDL-P, LDL III-P, LDL IV-P, total HDL-P, and HDL 2b-P), and additional cardiovascular biomarkers (apo B-100, lipoprotein [a], high-sensitivity C-reactive protein, homocysteine, fibrinogen, and insulin) were measured at baseline, after 4 weeks, and after 8 weeks.Results:Remnant lipoprotein particles decreased by 15.5% (p=0.03) over the 8-week period. The remaining outcome measures were not significantly altered.Conclusions:In this pilot study, 8 weeks of daily supplementation withS. boulardiilowered remnant lipoprotein, a predictive biomarker and potential therapeutic target in the treatment and prevention of coronary artery disease.
登录
查看更多内容
影响因子：
6.5
作者：
F. Karpe;S. Boquist;Rong Tang;Gene M. Bond;U. Faire;Anders Hamsten
通讯作者：
F. Karpe;S. Boquist;Rong Tang;Gene M. Bond;U. Faire;Anders Hamsten
影响因子：
168.9
作者：
Lozano, Rafael;Naghavi, Mohsen;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
3.4
作者：
Rosenson, Robert S.;Underberg, James A.
通讯作者：
Underberg, James A.
心源性猝死病例中血浆富含甘油三酯的脂蛋白残余物与冠状动脉粥样硬化的关联。
影响因子：
5.3
作者：
S. Takeichi;Nobuhiro Yukawa;Y. Nakajima;Motoki Osawa;Takeshi Saito;Y. Seto;T. Nakano;Abby R. Saniabadi;Masakazu Adachi;Tao Wang;Katsuyuki Nakajima
通讯作者：
Katsuyuki Nakajima