Circadian Variations of Salivary Stress Marker (Chromogranin A)
Circadian Variations of Salivary Stress Marker (Chromogranin A)
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唾液压力标记物（嗜铬蛋白 A）的昼夜变化
DOI：
10.2186/prp.7.189
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
R. Hosokawa
中科院分区：
文献类型：
--
作者：
M. Makino;C. Masaki;Kei Tomoeda;Megumi Takenaka;T. Kojo;Shigeki Murakami;R. Hosokawa
磨牙症是一种非常常见的咀嚼系统功能异常。目前，人们对磨牙症病因的多因素性质达成共识，认为它是一种与压力和疼痛行为相关的中枢神经系统现象，而不是结构成分。磨牙症和主观压力的关系仍然不清楚。最近，生物标志物已被用于评估应激反应，如嗜铬粒蛋白A（CgA）和皮质醇。CgA水平为评价心理应激提供了一个敏感、可靠的指标。关于血浆CgA的报道很多，但关于唾液CgA的报道还不够。本研究的目的是阐明唾液中CgA的昼夜变化。4名成年人（1名男性，3名女性）参与了本研究。受试者提供10份唾液样本。在早晨（9 am）和晚上（21 pm）采集唾液样本，每3 h采集一次，共24 h。此外，唾液样品是两分钟刺激和未刺激的样品，以测量CgA浓度，主要的唾液应激生物标志物。未刺激的唾液CgA浓度变化更大的时间和个体差异比刺激。刺激的唾液CgA浓度从12 pm增加到18 pm。唾液中CgA的含量呈现昼夜节律变化，高峰在下午-夜间，最低点在中午。关于昼夜变化，唾液CgA浓度，特别是刺激唾液，几乎没有不同的血浆CgA。CgA浓度受多种因素的影响。
Bruxism is a very common parafunction of the masticatory system. Currently, there is consensus about the multifactorial nature of the etiology of bruxism, and it is thought to be a central nervous system phenomenon related to stress and pain behavior rather than structural components. The relationship of bruxism and subjective stress has remained unclear. Recently, biomarkers have been used for assessing stress reaction such as chromogranin A (CgA) and cortisol. The level of CgA provides a sensitive and reliable index for evaluating psychological stress. We can have many reports about plasma CgA, but we can't have enough reports about salivary CgA. The aim of this study was to clarify circadian variation CgA in saliva. Four adults (1 male, 3 females) participated in this research. Subjects provided ten saliva samples. Saliva samples were collected in the morning (9 am) and in the night (21 pm), and every 3 h for 24 h. In addition, saliva samples were two-minute stimulated and unstimulated samples to measure CgA concentration, major salivary stress biomarkers. Unstimulated salivary CgA concentration varied more in time and individual difference than stimulated. Stimulated salivary CgA concentration was increased from 12 pm to 18 pm. Salivary CgA seemed to have a circadian variation with peak in the afternoon-night period and a nadir in the noon. With regard to circadian variations, salivary CgA concentrations, in particular stimulated saliva, hardly differ from plasma CgA. It was concerned that CgA concentration was influenced from a lot of factors.
人类嗜铬粒蛋白 A 的超电变化。
DOI：
10.1152/ajpregu.1991.261.4.r939
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
--
作者：
Takiyyuddin,MA;Neumann,HP;Cervenka,JH;Kennedy,B;Dinh,TQ;Ziegler,MG;Baron,AD;O'Connor,DT
通讯作者：
O'Connor,DT