Esophageal pressure topography criteria indicative of incomplete bolus clearance: a study using high-resolution impedance manometry.
Esophageal pressure topography criteria indicative of incomplete bolus clearance: a study using high-resolution impedance manometry.
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DOI：
10.1038/ajg.2009.467
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发表时间：
2009-11
影响因子：
9.8
通讯作者：
Pandolfino, John E.
中科院分区：
文献类型：
--
作者：
Bulsiewicz, William J.;Kahrilas, Peter J.;Kwiatek, Monika A.;Ghosh, Sudip K.;Meek, Albert;Pandolfino, John E.
本研究使用高分辨率阻抗测压法（HRIM）确定蠕动完整性的压力地形图阈值，以预测不完全的食管食团清除。共16名正常对照和8例吞咽困难患者进行了研究，使用固态HRIM组件，包括36个测压传感器和12个阻抗段。每项研究中的10次盐水吞咽均根据阻抗标准分为完全或不完全清除，并使用压力地形图等压轮廓（范围为10 - 30 mm Hg，增量为5 mm Hg）评价蠕动完整性。每个等压等值线图的特征在于等压等值线中的断裂的位置和长度。所有受试者的食管胃连接部（EGJ）松弛均正常，无受试者符合食管裂孔疝的压力地形图标准。总体而言，240次吞咽中有70次（29%）的大剂量清除不完全。在每种情况下，完整的≥20 mm Hg等压轮廓与完全的推注清除相关。在20 mm Hg和30 mm Hg等压轮廓中，与完全食团清除相关的最大缺陷长度分别为1.7 cm和3.0 cm，而预测不完全食团清除的最小缺陷长度分别为2.1 cm和3.2 cm。在EGJ松弛和形态正常的个体中，20 mm Hg等压轮廓中中断<2 cm或30 mm Hg等压轮廓中中断<3 cm的蠕动收缩与完全的食团清除相关，更长的中断预示不完全的食团清除。
This study used high-resolution impedance manometry (HRIM) to determine pressure topography thresholds of peristaltic integrity predictive of incomplete esophageal bolus clearance. A total of 16 normal controls and 8 patients with dysphagia were studied using a solid-state HRIM assembly incorporating 36 manometric sensors and 12 impedance segments. Each of the 10 saline swallows in each study was dichotomously scored as either complete or incomplete bolus clearance by impedance criteria, and peristaltic integrity was evaluated using pressure topography isobaric contours ranging from 10 to 30 mm Hg in 5-mm Hg increments. Each isobaric contour plot was characterized by the location and length of breaks in the isobaric contour. All subjects had normal esophagogastric junction (EGJ) relaxation and none met the pressure topography criteria of hiatus hernia. In all, 70 (29%) of the 240 individual swallows had incomplete bolus clearance. In every case, an intact ≥20 mm Hg isobaric contour was associated with complete bolus clearance. The largest defect in the 20 and 30 mm Hg isobaric contours associated with complete bolus clearance measured 1.7 and 3.0 cm, respectively, in length, whereas the smallest defect predictive of incomplete bolus clearance measured 2.1 and 3.2 cm, respectively. In individuals with normal EGJ relaxation and morphology, peristaltic contractions with breaks <2 cm in the 20 mm Hg isobaric contour or <3 cm in the 30 mm Hg isobaric contour are associated with complete bolus clearance, and longer breaks predict incomplete bolus clearance.
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影响因子：
--
作者：
REN, JL;MASSEY, BT;ARNDORFER, RC
通讯作者：
ARNDORFER, RC
DOI：
10.1016/j.bpg.2007.12.007
发表时间：
2008-01-01
影响因子：
3.2
作者：
Kahrilas, Peter J.;Kim, Hyon C.;Pandolfino, John E.
通讯作者：
Pandolfino, John E.
影响因子：
3.5
作者：
Ghosh SK;Pandolfino JE;Kwiatek MA;Kahrilas PJ
通讯作者：
Kahrilas PJ
影响因子：
2.9
作者：
Kahrilas, Peter J.;Ghosh, Sudip K.;Pandolfino, John E.
通讯作者：
Pandolfino, John E.
影响因子：
29.4
作者：
SLOAN, S;KAHRILAS, PJ
通讯作者：
KAHRILAS, PJ