COVID-19 and hypertension: Is there a role for dsRNA and activation of Toll-like receptor 3?
COVID-19 and hypertension: Is there a role for dsRNA and activation of Toll-like receptor 3?
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DOI：
10.1016/j.vph.2021.106861
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发表时间：
2021-10
影响因子：
4
通讯作者：
Webb RC
中科院分区：
文献类型：
--
作者：
Dela Justina V;Giachini FR;Priviero F;Webb RC
导致2019年冠状病毒病（COVID-19）的病毒是严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）。有证据表明，COVID-19可能会在表面健康的患者中引发心血管并发症。冠状病毒是一种有包膜的正链RNA病毒，具有病原体相关分子模式（PAMP）/病原体相关分子模式（DAMP）。有趣的是，Toll样受体（TLR）3识别PAMP和DAMP，并被病毒双链RNA（dsRNA）激活，导致含有TIR受体结构域的衔接子诱导IFN-β（TRIF）依赖性途径的激活。新的证据表明病毒dsRNA与血压升高之间存在联系。因此，我们假设COVID-19感染可能通过dsRNA过度激活TLR 3，对患者造成进一步损害，导致血管炎症和血压升高，有利于发展多种心血管并发症，包括高血压。
The virus responsible for the coronavirus disease of 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidences suggest that COVID-19 could trigger cardiovascular complications in apparently healthy patients. Coronaviruses are enveloped positive-strand RNA viruses acting as a pathogen-associated molecular pattern (PAMP)/ danger-associated molecular patterns (DAMP). Interestingly, Toll-like receptor (TLR) 3 recognize both PAMPs DAMPs and is activated by viral double-stranded RNA (dsRNA) leading to activation of TIR receptor domain-containing adaptor inducing IFN-β (TRIF) dependent pathway. New evidence has shown a link between virus dsRNA and increased BP. Hence, we hypothesize that COVID-19 infection may be over activating the TLR3 through dsRNA, evoking further damage to the patients, leading to vascular inflammation and increased blood pressure, favoring the development of several cardiovascular complications, including hypertension.
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