Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines.
Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines.
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DOI：
10.1098/rsob.200160
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发表时间：
2020-09
期刊：
影响因子：
5.8
通讯作者：
Assas BM
中科院分区：
文献类型：
--
作者：
Fara A;Mitrev Z;Rosalia RA;Assas BM
2019冠状病毒病（COVID-19）席卷全球，不同于过去50年来的任何其他大流行病。自疫情爆发以来，我们对该疾病的认识迅速发展;疾病预后主要受多器官受累的影响。急性呼吸窘迫综合征、心力衰竭、肾衰竭、肝损伤、休克和多器官衰竭与发病率和死亡率密切相关。COVID-19疾病病理学与以病理性细胞因子水平为特征的身体炎症反应密切相关。“细胞因子风暴综合征”一词可能是COVID-19疾病严重程度的关键标志之一。在这篇综述中，我们强调了突出的细胞因子家族及其在COVID-19中的潜在作用，I型和II型干扰素，肿瘤坏死因子和白细胞介素家族的成员。我们解决了各种变化的细胞成分的免疫反应证实细胞因子水平的变化，同时讨论细胞因子的来源和生物功能。最后，我们简要讨论了试图调节细胞因子风暴的潜在疗法。
Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; disease prognosis is influenced mainly by multi-organ involvement. Acute respiratory distress syndrome, heart failure, renal failure, liver damage, shock and multi-organ failure are strongly associated with morbidity and mortality. The COVID-19 disease pathology is plausibly linked to the hyperinflammatory response of the body characterized by pathological cytokine levels. The term ‘cytokine storm syndrome’ is perhaps one of the critical hallmarks of COVID-19 disease severity. In this review, we highlight prominent cytokine families and their potential role in COVID-19, the type I and II interferons, tumour necrosis factor and members of the Interleukin family. We address various changes in cellular components of the immune response corroborating with changes in cytokine levels while discussing cytokine sources and biological functions. Finally, we discuss in brief potential therapies attempting to modulate the cytokine storm.
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DOI：
10.1084/jem.20031051
发表时间：
2003-11-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Berg RE;Crossley E;Murray S;Forman J
通讯作者：
Forman J
影响因子：
4.6
作者：
Bester J;Pretorius E
通讯作者：
Pretorius E
影响因子：
8.3
作者：
Angelopoulou, Athina;Alexandris, Nikos;Poulas, Konstantinos
通讯作者：
Poulas, Konstantinos
DOI：
10.1016/j.jaip.2020.06.015
发表时间：
2020-09-01
影响因子：
9.4
作者：
Chang, De;Zhao, Peng;Qin, En-Qiang
通讯作者：
Qin, En-Qiang
DOI：
10.1016/j.dsx.2020.04.020
发表时间：
2020-07-01
影响因子：
10
作者：
Astuti, Indwiani;Ysrafil
通讯作者：
Ysrafil