Defective HLA class I antigen processing machinery in cancer.
Defective HLA class I antigen processing machinery in cancer.
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DOI：
10.1007/s00262-018-2131-2
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Ferrone S
中科院分区：
文献类型：
--
作者：
Cai L;Michelakos T;Yamada T;Fan S;Wang X;Schwab JH;Ferrone CR;Ferrone S
细胞的恶性转化通常与有缺陷的HLA I类抗原加工机制（APM）组分表达相关。这种异常可能具有功能相关性，因为它可能对同源T细胞识别肿瘤细胞产生负面影响。此外，HLA I类APM异常似乎具有临床意义，因为它们与几种恶性疾病的预后不良相关，并且可能在对基于免疫检查点通道的免疫治疗的抵抗中发挥作用。在本文中，我们回顾了文献中描述的异常HLA I类APM组件的表达在许多类型的癌症。在所有类型的癌症分析中均报告了这些异常，HLA I类重链的频率范围为肾癌中最低35.8%和甲状腺癌中最高87.9%。此外，我们已经描述了HLA I类APM组分表达和恶性细胞功能缺陷的分子机制。最后，我们讨论了恶性肿瘤中HLA-I类APM组分异常的临床意义。
Malignant transformation of cells is frequently associated with defective HLA class I antigen processing machinery (APM) component expression. This abnormality may have functional relevance, since it may have a negative impact on tumor cell recognition by cognate T cells. Furthermore, HLA class I APM abnormalities appear to have clinical significance, since they are associated with poor prognosis in several malignant diseases and may play a role in the resistance to immune checkpoint inhibitor-based immunotherapy. In this paper, we have reviewed the literature describing abnormalities in HLA class I APM component expression in many types of cancer. These abnormalities have been reported in all types of cancer analyzed with a frequency ranging between a minimum of 35.8% in renal cancer and a maximum of 87.9% in thyroid cancer for HLA class I heavy chains. In addition, we have described the molecular mechanisms underlying defects in HLA class I APM component expression and function by malignant cells. Lastly, we have discussed the clinical significance of HLA class I APM component abnormalities in malignant tumors.
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影响因子：
11.2
作者：
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通讯作者：
Svane, Inge Marie
影响因子：
7.4
作者：
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通讯作者：
Marincola FM
影响因子：
4.8
作者：
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通讯作者：
Ferrone, Soldano
影响因子：
11.5
作者：
Fonsatti, Ester;Nicolay, Hugues J. M.;Maio, Michele
通讯作者：
Maio, Michele
DOI：
10.1016/s1091-255x(97)80051-0
发表时间：
1997-07-01
期刊：
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
影响因子：
--
作者：
Hosch, S B;Meyer, A J;Izbicki, J R
通讯作者：
Izbicki, J R