Transcription factors are targeted by differentially expressed miRNAs in primates.
Transcription factors are targeted by differentially expressed miRNAs in primates.
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DOI：
10.1093/gbe/evs033
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发表时间：
2012
影响因子：
3.3
通讯作者：
Kelso J
中科院分区：
文献类型：
--
作者：
Dannemann M;Prüfer K;Lizano E;Nickel B;Burbano HA;Kelso J
MicroRNAs(MiRNAs)是参与哺乳动物基因表达调控的小RNA分子。MiRNAs与其他转录调节因子一起调节基因的表达，从而潜在地促进组织和物种的多样性。为了确定在组织和/或物种之间差异表达的miRNAs及其调控的基因，我们使用高通量测序技术对来自多个人、黑猩猩和恒河猴个体的五个组织中miRNAs和信使RNA的表达进行了量化。这些组织和物种数据的广度使我们能够表明，miRNAs对靶基因的下调在组织间比物种间更明显，而且表达的miRNAs结合位点较少的基因下调更明显。有趣的是，我们发现组织和物种特异的miRNAs靶向转录因子基因(TF)的频率比预期的要高得多。因此，通过对转录因子的调节作用，miRNAs可能会对比之前认为的更大比例的基因产生间接影响。
MicroRNAs (miRNAs) are small RNA molecules involved in the regulation of mammalian gene expression. Together with other transcription regulators, miRNAs modulate the expression of genes and thereby potentially contribute to tissue and species diversity. To identify miRNAs that are differentially expressed between tissues and/or species, and the genes regulated by these, we have quantified expression of miRNAs and messenger RNAs in five tissues from multiple human, chimpanzee, and rhesus macaque individuals using high-throughput sequencing. The breadth of this tissue and species data allows us to show that downregulation of target genes by miRNAs is more pronounced between tissues than between species and that downregulation is more pronounced for genes with fewer binding sites for expressed miRNAs. Intriguingly, we find that tissue- and species-specific miRNAs target transcription factor genes (TFs) significantly more often than expected. Through their regulatory effect on transcription factors, miRNAs may therefore exert an indirect influence on a larger proportion of genes than previously thought.
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影响因子：
3.7
作者：
Creighton CJ;Benham AL;Zhu H;Khan MF;Reid JG;Nagaraja AK;Fountain MD;Dziadek O;Han D;Ma L;Kim J;Hawkins SM;Anderson ML;Matzuk MM;Gunaratne PH
通讯作者：
Gunaratne PH
影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
3.1
作者：
Baev, Vesselin;Daskalova, Evelina;Minkov, Ivan
通讯作者：
Minkov, Ivan
Mirbase：MicroRNA基因组学的工具。
影响因子：
14.9
作者：
Griffiths-Jones, Sam;Saini, Harpreet Kaur;van Dongen, Stijn;Enright, Anton J.
通讯作者：
Enright, Anton J.
影响因子：
4.5
作者：
Hu HY;Guo S;Xi J;Yan Z;Fu N;Zhang X;Menzel C;Liang H;Yang H;Zhao M;Zeng R;Chen W;Pääbo S;Khaitovich P
通讯作者：
Khaitovich P