Epigenetic regulation of adipogenesis by histone methylation.
Epigenetic regulation of adipogenesis by histone methylation.
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DOI：
10.1016/j.bbagrm.2011.12.008
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发表时间：
2012-07
影响因子：
4.7
通讯作者：
Ge, Kai
中科院分区：
文献类型：
--
作者：
Ge, Kai
组蛋白甲基化与基因激活和抑制有关，这取决于被甲基化的特定赖氨酸残基。近年来，组蛋白甲基化酶和去甲基化酶的数量急剧增加，这为研究组蛋白甲基化在哺乳动物细胞基因表达和细胞分化中的生物学功能提供了新的途径。脂肪生成是一个很好的模型系统，以了解转录和表观遗传调控的基因表达和细胞分化。虽然脂肪形成的转录调控已被广泛研究，但表观遗传机制，特别是组蛋白甲基化在脂肪形成调控中的作用才刚刚开始被理解。本文就组蛋白H3K4和H3K27甲基化对脂肪形成的表观遗传调控的研究进展作一综述。现有的证据表明，位点特异性组蛋白甲基化在脂肪形成中起关键作用，并控制脂肪形成的正性和负性主调节因子的表达。
Histone methylation is implicated in both gene activation and repression, depending on the specific lysine residue that gets methylated. Recent years have witnessed an explosive expansion of the list of remarkably site-specific histone methyltransferases and demethylases, which greatly facilitates the study on the biological functions of histone methylation in gene expression and cell differentiation in mammalian cells. Adipogenesis represents an excellent model system to understand transcriptional and epigenetic regulation of gene expression and cell differentiation. While transcriptional regulation of adipogenesis has been extensively studied, the roles of epigenetic mechanisms in particular histone methylation in regulation of adipogenesis have just begun to be understood. This review will summarize the recent progress on epigenetic regulation of adipogenesis by histone methylation, with a focus on histone H3K4 and H3K27. The available evidence suggests that site-specific histone methylations play critical roles in adipogenesis and control the expression of both positive and negative master regulators of adipogenesis.
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影响因子：
64.8
作者：
Heintzman, Nathaniel D.;Hon, Gary C.;Hawkins, R. David;Kheradpour, Pouya;Stark, Alexander;Harp, Lindsey F.;Ye, Zhen;Lee, Leonard K.;Stuart, Rhona K.;Ching, Christina W.;Ching, Keith A.;Antosiewicz-Bourget, Jessica E.;Liu, Hui;Zhang, Xinmin;Green, Roland D.;Lobanenkov, Victor V.;Stewart, Ron;Thomson, James A.;Crawford, Gregory E.;Kellis, Manolis;Ren, Bing
通讯作者：
Ren, Bing
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1073/pnas.0707292104
发表时间：
2007-11-20
影响因子：
11.1
作者：
Hong, SunHwa;Cho, Young-Wook;Ge, Kai
通讯作者：
Ge, Kai
影响因子：
64.5
作者：
Garcia-Bassets, Ivan;Kwon, Young-Soo;Rosenfeld, Michael G.
通讯作者：
Rosenfeld, Michael G.
DOI：
10.1073/pnas.2536828100
发表时间：
2003-12-23
影响因子：
11.1
作者：
He, WM;Barak, Y;Evans, RM
通讯作者：
Evans, RM