Action of phenolic antioxidants on various active oxygen species.
Action of phenolic antioxidants on various active oxygen species.
复制标题
酚类抗氧化剂对各种活性氧的作用。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
Y. Fujita
中科院分区：
文献类型：
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作者：
O. Cynshi;Y. Takashima;Yoshiaki Katoh;K. Tamura;Mitsuo Sato;Y. Fujita
用鲁米诺化学发光法和5，5-二甲基-1-吡咯啉-N-氧化物（DMPO）自旋捕集法研究了酚类抗氧化剂普罗布考对各种活性氧的作用。研究了酚类抗氧化剂在水溶液和非水溶液中对羟基自由基（芬顿反应）、超氧阴离子、单线态氧和次氯酸根离子的影响。普罗布考在非水溶液中对超氧阴离子和次氯酸根离子均有猝灭作用。然而，它对羟基自由基没有影响。天然酚类抗氧化剂α-生育酚对超氧阴离子和次氯酸根离子的猝灭作用强于普罗布考，对非水溶液中的羟基自由基的猝灭作用也强于普罗布考。此外，Trolox在水溶液和非水溶液中对所有活性氧物种都表现出猝灭作用。在一系列测试系统中，在可比条件下研究了抗氧化剂，并将反应性曲线描绘为有助于表征抗氧化作用的“雷达图”。
The action of phenolic antioxidants, such as probucol, on various active oxygen species was investigated using luminol chemiluminescence and spin trapping with 5,5-dimethyl-1-pyrroline-N-oxide (DMPO). The various active oxygen species, including hydroxyl radicals (Fenton reaction), superoxide anions, singlet oxygen and hypochlorite ions were examined with phenolic antioxidants under aqueous and nonaqueous conditions. Probucol showed a quenching effect on both superoxide anions and hypochlorite ions in nonaqueous solution. However, it had no effect on hydroxyl radicals. alpha-Tocopherol, a natural phenolic antioxidant, showed a stronger quenching effect on superoxide anions and hypochlorite ions than probucol, and quenched hydroxyl radicals in nonaqueous solution. Furthermore, Trolox showed a quenching effect on all active oxygen species in both aqueous and nonaqueous solution. The antioxidants were studied under comparable conditions in a series of test systems and the reactivity profiles depicted as 'radar charts' which are helpful for characterizing antioxidant action.
影响因子：
15.9
作者：
PARTHASARATHY, S;YOUNG, SG;STEINBERG, D
通讯作者：
STEINBERG, D
普罗布考剂量对血浆脂质和脂蛋白水平以及对低密度脂蛋白对人体体外氧化的保护的影响。
DOI：
10.1161/01.atv.12.3.318
发表时间：
1992
期刊：
Arteriosclerosis and thrombosis : a journal of vascular biology
影响因子：
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作者：
Reaven,PD;Parthasarathy,S;Beltz,WF;Witztum,JL
通讯作者：
Witztum,JL