Effect of probucol dosage on plasma lipid and lipoprotein levels and on protection of low density lipoprotein against in vitro oxidation in humans.
Effect of probucol dosage on plasma lipid and lipoprotein levels and on protection of low density lipoprotein against in vitro oxidation in humans.
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普罗布考剂量对血浆脂质和脂蛋白水平以及对低密度脂蛋白对人体体外氧化的保护的影响。
DOI：
10.1161/01.atv.12.3.318
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Witztum,JL
中科院分区：
文献类型：
--
作者：
Reaven,PD;Parthasarathy,S;Beltz,WF;Witztum,JL
为了确定普罗布考对低密度脂蛋白（LDL）的抗氧化保护能力是否与其降低高密度脂蛋白（HDL）胆固醇的能力无关，17名高胆固醇血症患者接受了6个月的普罗布考治疗，标准剂量为1 g/天（4片），或低剂量为250 mg/天（1片）。治疗对脂蛋白水平和LDL体外氧化敏感性的影响以频繁的时间间隔进行测量。在6个月后，1片组血浆LDL中的普罗布考水平上升较慢，但接近4片组水平的50%。1片组HDL胆固醇和载脂蛋白A-1分别降低17.6%和27.9%，而4片组分别降低28.0%和38.3%（p = 0.07和p = 0.06）。在4片组中，治疗2个月后，LDL受到铜和内皮细胞介导的氧化的保护。在1片组中，发生了同等程度的保护，但仅在治疗6个月后。在整个研究组中，LDL对铜或内皮细胞介导的氧化修饰的敏感性降低与LDL中普罗布考的含量相关（r = 0.73，r = 0.65，p <0.005）。此外，HDL胆固醇水平的降低与LDL免受氧化修饰的保护的增加相关（对于铜，r = 0.67，对于内皮细胞，r = 0.58，两者p均小于0.05），并且还与LDL中普罗布考的含量相关（r = 0.6，p = 0.01）。（250字处删节）
To determine whether probucol's ability to confer antioxidant protection to low density lipoprotein (LDL) could be dissociated from its ability to lower high density lipoprotein (HDL) cholesterol, 17 hypercholesterolemic patients were treated with either a standard dose, 1 g/day (4 tablets), or a low dose, 250 mg/day (1 tablet), of probucol for a 6-month period. Effects of therapy on lipoprotein levels and on susceptibility of LDL to in vitro oxidation were measured at frequent intervals. Probucol levels in plasma LDL rose less rapidly in the 1-tablet group but were nearly 50% of levels in the 4-tablet group after 6 months. HDL cholesterol and apolipoprotein A-1 decreased 17.6% and 27.9%, respectively, in the 1-tablet group compared with 28.0% and 38.3%, respectively, in the 4-tablet group (p = 0.07 and p = 0.06). In the 4-tablet group, LDL was protected from copper and endothelial cell-mediated oxidation after 2 months of therapy. In the 1-tablet group, equal degrees of protection occurred, but only after 6 months of therapy. In the whole study group, the decrease in LDL susceptibility to copper or endothelial cell-mediated oxidative modification was correlated with the content of probucol in LDL (r = 0.73, r = 0.65, p less than 0.005). Additionally, the decrease in HDL cholesterol level was correlated with the increase in protection to LDL from oxidative modification (r = 0.67 for copper, r = 0.58 for endothelial cells, p less than 0.05 for both) and also with the content of probucol in LDL (r = 0.6, p = 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
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DOI：
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发表时间：
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DOI：
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1990-05-22
期刊：
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作者：
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DOI：
--
发表时间：
1988
期刊：
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