Physiological properties of neurons in the ventral nucleus of the lateral lemniscus of the rat: intrinsic membrane properties and synaptic responses.
Physiological properties of neurons in the ventral nucleus of the lateral lemniscus of the rat: intrinsic membrane properties and synaptic responses.
复制标题
大鼠外侧丘系腹核神经元的生理特性：内在膜特性和突触反应。
DOI：
10.1152/jn.1999.81.6.2862
复制
发表时间：
1999
影响因子：
2.5
通讯作者：
S. Wu
中科院分区：
文献类型：
--
作者：
S. Wu
通过年轻大鼠（17-37 天大）听觉脑干的脑切片研究了外侧丘系 (VNLL) 腹侧核神经元的电流-电压关系、放电模式和突触反应等生理特性。细胞内记录是由 VNLL 神经元进行的，并且通过电刺激 VNLL 的外侧丘系腹侧来引发突触电位。通过记录细胞内注入正电流和负电流产生的电势来测试电流-电压关系和放电模式。有两种类型的 VNLL 神经元（I 型和 II 型）表现出不同的电流-电压关系。为了响应负电流，I 型和 II 型神经元均产生分级超极化。 I型神经元对正电流有分级去极化和多个动作电位的反应，动作电位的数量与注入电流的强度有关。 I型神经元的电流-电压关系接近线性。 II 型神经元对正电流有有限的去极化反应，并且只有一个或几个动作电位。 II型神经元在静息电位附近的电流-电压关系是非线性的。 II 型 VNLL 神经元的膜特性可能在处理有关声音出现时间的信息方面发挥重要作用。 I 型神经元响应小正电流，表现出三种不同的放电模式，即规则放电、起始暂停放电和适应放电。当注入大电流时，起始-暂停和适应模式可以持续。 I 型神经元中的规则、发作-暂停和适应模式以及 II 型神经元中的发作模式分别类似于体内 VNLL 研究中定义的“斩波”、“暂停”、“初级样”和“开启”反应。结果表明，对声刺激的不同反应可能归因于 VNLL 神经元的内在膜特性。许多 VNLL 神经元对外侧丘系的刺激做出兴奋性或抑制性反应或两者兼而有之。兴奋性和抑制性反应表现出相互作用，突触整合的输出取决于兴奋性和抑制性反应的相对强度。具有开始-暂停放电模式的神经元更有可能从下听觉脑干接收混合的兴奋性和抑制性输入。
The physiological properties including current-voltage relationships, firing patterns, and synaptic responses of the neurons in the ventral nucleus of the lateral lemniscus (VNLL) were studied in brain slices taken through the young rat's (17-37 days old) auditory brain stem. Intracellular recordings were made from VNLL neurons, and synaptic potentials were elicited by electrical stimulation of the lateral lemniscus ventral to the VNLL. Current-voltage relations and firing patterns were tested by recording the electrical potentials produced by intracellular injection of positive and negative currents. There were two types of VNLL neurons (type I and II) that exhibited different current-voltage relationships. In response to negative current, both type I and II neurons produced a graded hyperpolarization. Type I neurons responded to positive current with a graded depolarization and multiple action potentials the number of which was related to the strength of the current injected. The current-voltage relations of type I neurons were nearly linear. Type II neurons responded to positive current with a limited depolarization and only one or a few action potentials. The current-voltage relations of type II neurons were nonlinear near the resting potential. The membrane properties of the type II VNLL neurons may play an important role for processing information about time of onset of a sound. Type I neurons showed three different firing patterns, i.e., regular, onset-pause and adaptation, in response to small positive current. The onset-pause and adaptation patterns could become sustained when a large current was injected. The regular, onset-pause, and adaptation patterns in type I neurons and the onset pattern in type II neurons resemble "chopper," "pauser, " "primary-like," and "on" responses, respectively, as defined in in vivo VNLL studies. The results suggest that different responses to acoustic stimulation could be attributed to intrinsic membrane properties of VNLL neurons. Many VNLL neurons responded to stimulation of the lateral lemniscus with excitatory or inhibitory responses or both. Excitatory and inhibitory responses showed interaction, and the output of the synaptic integration depended on the relative strength of excitatory and inhibitory responses. Neurons with an onset-pause firing pattern were more likely to receive mixed excitatory and inhibitory inputs from the lower auditory brain stem.
对外侧丘系腹侧核内侧部分的耳间时间差异敏感的神经元。
DOI：
10.1152/jn.1997.78.1.511
发表时间：
1997
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Batra,R;Fitzpatrick,DC
通讯作者：
Fitzpatrick,DC
结构和功能差异区分了豚鼠 MSO 切片中的主要细胞和非主要细胞。
DOI：
10.1152/jn.1995.73.4.1653
发表时间：
1995
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Smith,PH
通讯作者：
Smith,PH
猫梯形体（MNTB）内侧核主要细胞的解剖学和生理学。
影响因子：
2.5
作者：
Smith,PH;Joris,PX;Yin,TC
通讯作者：
Yin,TC