Scaffold proteins: hubs for controlling the flow of cellular information.
Scaffold proteins: hubs for controlling the flow of cellular information.
复制标题
DOI：
10.1126/science.1198701
复制
发表时间：
2011-05-06
期刊：
影响因子：
--
通讯作者：
Lim WA
中科院分区：
文献类型：
--
作者：
Good MC;Zalatan JG;Lim WA
细胞内分子的空间和时间组织对于协调细胞进行的许多不同活动至关重要。在越来越多的生物信号传导过程中，已经发现支架蛋白在相关分子组分的物理组装中发挥核心作用。虽然大多数支架使用简单的拴系机制来提高单个伴侣分子之间的相互作用效率，但这些蛋白质也可以对其伴侣施加复杂的变构控制，并且本身就是调控的目标。支架蛋白提供了一种简单，灵活的策略，用于调节通路的选择性，塑造输出行为，并从预先存在的信号成分中获得新的反应。因此，支架蛋白已被进化、病原体和细胞工程师利用来重塑细胞行为。
The spatial and temporal organization of molecules within a cell is critical for coordinating the many distinct activities carried out by the cell. In an increasing number of biological signaling processes, scaffold proteins have been found to play a central role in physically assembling the relevant molecular components. Although most scaffolds use a simple tethering mechanism to increase the efficiency of interaction between individual partner molecules, these proteins can also exert complex allosteric control over their partners and are themselves the target of regulation. Scaffold proteins offer a simple, flexible strategy for regulating selectivity in pathways, shaping output behaviors, and achieving new responses from preexisting signaling components. As a result, scaffold proteins have been exploited by evolution, pathogens, and cellular engineers to reshape cellular behavior.
登录
查看更多内容
影响因子：
64.5
作者：
Good M;Tang G;Singleton J;Reményi A;Lim WA
通讯作者：
Lim WA
影响因子：
56.9
作者：
Bashor, Caleb J.;Helman, Noah C.;Lim, Wendell A.
通讯作者：
Lim, Wendell A.
影响因子：
64.8
作者：
Brennan, Damian F.;Dar, Arvin C.;Barford, David
通讯作者：
Barford, David
影响因子：
4.8
作者：
McDonald, C;Vacratsis, PO;Dixon, JE
通讯作者：
Dixon, JE
DOI：
10.1073/pnas.0706311104
发表时间：
2007-08-14
影响因子：
11.1
作者：
Locasale, Jason W.;Shaw, Andrey S.;Chakraborty, Arup K.
通讯作者：
Chakraborty, Arup K.