Brain 5-HT uptake sites, labelled with [3H]paroxetine, in antidepressant-free depressed suicides
Brain 5-HT uptake sites, labelled with [3H]paroxetine, in antidepressant-free depressed suicides
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用[3H]帕罗西汀标记的大脑 5-HT 摄取位点，用于未服用抗抑郁药物的抑郁症自杀者
DOI：
10.1016/0006-8993(90)90244-6
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发表时间：
1990
期刊：
影响因子：
2.9
通讯作者：
R. Horton
中科院分区：
文献类型：
--
作者：
K. Lawrence;F. Paermentier;S. Cheetham;M. Crompton;C. Katona;R. Horton
Brain serotonin (5-HT) uptake sites were quantitated, by saturation binding of [3H]paroxetine, in 10 brain regions from 22 suicide victims and 20 control subjects. Suicide victims were restricted to those subjects in whom a firm retrospective diagnosis of depression was established and who had not recently been prescribed antidepressant drugs. TheKdandBmaxof [3H]paroxetine did not differ significantly between controls and depressed suicides in any of the brain regions. In putamen,Bmaxvalues of suicides who died non-violently were lower than controls, whereas those who died by violent methods did not differ from controls. No significant differences between violent or non-violent suicides and their matched controls were found in other brain areas. These results offer little support for the view that suicide/depression is associated with an abnormality in 5-HT uptake.
影响因子：
--
作者：
H. Meltzer;Ramesh Chandra Arora;R. Baber;B. J. Tricou
通讯作者：
H. Meltzer;Ramesh Chandra Arora;R. Baber;B. J. Tricou
[3H]西酞普兰选择性标记大鼠大脑中的血清素摄取位点与[3H]丙咪嗪标记多个位点形成对比。
DOI：
--
发表时间：
1987
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
D'Amato,RJ;Largent,BL;Snowman,AM;Snyder,SH
通讯作者：
Snyder,SH