Applications of high-resolution magic angle spinning MRS in biomedical studies II-Human diseases.
Applications of high-resolution magic angle spinning MRS in biomedical studies II-Human diseases.
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高分辨率魔角旋转MRS在生物医学研究中的应用II-人类疾病
DOI：
10.1002/nbm.3784
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发表时间：
2017-11
影响因子：
2.9
通讯作者：
Cheng LL
中科院分区：
文献类型：
--
作者：
Dietz C;Ehret F;Palmas F;Vandergrift LA;Jiang Y;Schmitt V;Dufner V;Habbel P;Nowak J;Cheng LL
高分辨率魔角旋转（HRMAS）磁共振波谱（MRS）是一种有效的方法，用于深入了解细胞代谢的生理和病理过程。鉴于其获得非液体生物样品的高分辨率光谱的能力，同时保留组织结构用于随后的组织病理学分析，该技术已成为生物化学和生物医学研究的宝贵。使用HRMAS MRS，测量的代谢物，代谢率和代谢组学谱的改变，提出了可能性，以提高各种疾病的识别和解释，并破译药物治疗的代谢组学的影响。在这篇综述中，我们评估HRMAS MRS结果对人类组织标本的恶性肿瘤和非本地化疾病的文献报道，自1996年开始的技术。我们提出了不同的应用程序的技术在理解不同的解剖起源，在体内成像，治疗的有效性，并在HRMAS方法的进展的相关性的病理过程。高分辨率魔角自旋（HRMAS）磁共振波谱（MRS）是一种提高非液体生物样品分辨率的方法。自1996年引入以来，HRMAS已被用于各种生物医学和生物化学研究，是代谢组学分析中使用的主要技术之一。在这篇综述中，HRMAS结果对人类组织恶性肿瘤和非本地化疾病进行了评估，与应用程序的讨论，了解病理过程，与体内成像，治疗效果和方法的进展的相关性。
High-resolution magic angle spinning (HRMAS) magnetic resonance spectroscopy (MRS) is a powerful method for gaining insight into the physiological and pathological processes of cellular metabolism. Given its ability to obtain high resolution spectra of non-liquid biological samples, while preserving tissue architecture for subsequent histopathological analysis, the technique has become invaluable for biochemical and biomedical studies. Using HRMAS MRS, alterations in measured metabolites, metabolic ratios, and metabolomic profiles present the possibility to improve identification and prognostication of various diseases and decipher the metabolomic impact of drug therapies. In this review, we evaluate HRMAS MRS results on human tissue specimens from malignancies and non-localized diseases reported in the literature since the inception of the technique in 1996. We present the diverse applications of the technique in understanding pathological processes of different anatomical origins, correlations with in vivo imaging, effectiveness of therapies, and progress in the HRMAS methodology. High resolution magic angle spinning (HRMAS) magnetic resonance spectroscopy (MRS) is a method which enhances resolution for non-liquid biological samples. Since its introduction in 1996, HRMAS has been used in a wide variety of biomedical and biochemical studies and is one of the major techniques used in metabolomic analysis. In this review, HRMAS results on human tissue malignancies and non-localized diseases are evaluated, with discussions of applications for understanding pathological processes, correlations with in vivo imaging, therapy effectiveness, and methodology progress.
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影响因子：
3.8
作者：
Borgan E;Sitter B;Lingjærde OC;Johnsen H;Lundgren S;Bathen TF;Sørlie T;Børresen-Dale AL;Gribbestad IS
通讯作者：
Gribbestad IS
DOI：
10.1016/s0360-3016(01)01630-3
发表时间：
2001-10-01
影响因子：
7
作者：
Brizel, DM;Schroeder, T;Mueller-Klieser, W
通讯作者：
Mueller-Klieser, W
影响因子：
3.8
作者：
Cao MD;Giskeødegård GF;Bathen TF;Sitter B;Bofin A;Lønning PE;Lundgren S;Gribbestad IS
通讯作者：
Gribbestad IS
影响因子：
5.2
作者：
Andronesi, Ovidiu C.;Blekas, Konstantinos D.;Tzika, A. Aria
通讯作者：
Tzika, A. Aria
影响因子：
15.9
作者：
Cheng, LL;Anthony, DC;Gonzalez, RG
通讯作者：
Gonzalez, RG