An Uninvited Seat at the Dinner Table: How Apicomplexan Parasites Scavenge Nutrients from the Host.
An Uninvited Seat at the Dinner Table: How Apicomplexan Parasites Scavenge Nutrients from the Host.
复制标题
餐桌上的一个不速之客：顶复门寄生虫如何从宿主身上清除营养物质。
DOI：
10.3390/microorganisms9122592
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发表时间：
2021-12-15
期刊：
影响因子：
4.5
通讯作者：
Di Cristina M
中科院分区：
文献类型：
--
作者：
Piro F;Focaia R;Dou Z;Masci S;Smith D;Di Cristina M
专性细胞内寄生虫已经进化出一种引人注目的策略，从它们寄生的宿主细胞中吸收营养。大多数顶复虫在入侵的细胞内形成一个寄生虫空泡（PV），这是一个复制小生境，它们在其中生存和繁殖。除了提供针对宿主细胞防御机制的物理屏障外，PV膜（PVM）也是营养摄取的重要位点，这对于寄生虫维持其代谢至关重要。这意味着细胞外环境中的营养物质通过三种不同的膜与寄生虫代谢机制分离，即宿主质膜、PVM和寄生虫质膜（PPM）。为了促进营养物质从细胞外环境转运到寄生虫本身中，侵入细胞的宿主细胞膜上的转运蛋白可以通过分泌和输出的寄生虫蛋白质进行修饰，以最大限度地摄取关键底物以满足其代谢需求。为了克服第二个障碍，PVM，apicomplexan寄生虫分泌蛋白质包含在致密颗粒中，重塑液泡，使膜允许重要的营养物质。这种大量的宿主营养物质流之后，是一个更有选择性的摄取底物的PPM，这是由特定的转运这第三个障碍。在这篇综述中，我们概括和比较Apicomplexa开发的策略，从他们的主机，特别强调在寄生虫质膜和空泡溶质转运的寄生虫细胞内消化细胞器的转运。
Obligate intracellular parasites have evolved a remarkable assortment of strategies to scavenge nutrients from the host cells they parasitize. Most apicomplexans form a parasitophorous vacuole (PV) within the invaded cell, a replicative niche within which they survive and multiply. As well as providing a physical barrier against host cell defense mechanisms, the PV membrane (PVM) is also an important site of nutrient uptake that is essential for the parasites to sustain their metabolism. This means nutrients in the extracellular milieu are separated from parasite metabolic machinery by three different membranes, the host plasma membrane, the PVM, and the parasite plasma membrane (PPM). In order to facilitate nutrient transport from the extracellular environment into the parasite itself, transporters on the host cell membrane of invaded cells can be modified by secreted and exported parasite proteins to maximize uptake of key substrates to meet their metabolic demand. To overcome the second barrier, the PVM, apicomplexan parasites secrete proteins contained in the dense granules that remodel the vacuole and make the membrane permissive to important nutrients. This bulk flow of host nutrients is followed by a more selective uptake of substrates at the PPM that is operated by specific transporters of this third barrier. In this review, we recapitulate and compare the strategies developed by Apicomplexa to scavenge nutrients from their hosts, with particular emphasis on transporters at the parasite plasma membrane and vacuolar solute transporters on the parasite intracellular digestive organelle.
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影响因子：
4
作者：
De Koning, HP;Al-Salabi, MI;Wastling, JM
通讯作者：
Wastling, JM
DOI：
10.1124/jpet.103.059972
发表时间：
2004-06-01
影响因子：
3.5
作者：
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通讯作者：
Ravna, AW
影响因子：
4.8
作者：
Carter, NS;Ben Mamoun, C;Ullman, B
通讯作者：
Ullman, B
影响因子：
64.5
作者：
Coppens, I;Dunn, JD;Joiner, KA
通讯作者：
Joiner, KA
影响因子：
4.8
作者：
Al-Anouti, F;Tomavo, S;Ananvoranich, S
通讯作者：
Ananvoranich, S