National Mesothelioma Virtual Bank: a standard based biospecimen and clinical data resource to enhance translational research.
National Mesothelioma Virtual Bank: a standard based biospecimen and clinical data resource to enhance translational research.
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国家间皮瘤虚拟银行：一种基于标准的生物测量和临床数据资源，可增强转化研究。
DOI：
10.1186/1471-2407-8-236
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发表时间：
2008-08-13
期刊：
影响因子：
3.8
通讯作者：
Becich, Michael J.
中科院分区：
文献类型：
--
作者：
Amin, Waqas;Parwani, Anil V.;Schmandt, Linda;Mohanty, Sambit K.;Farhat, Ghada;Pople, Andrew K.;Winters, Sharon B.;Whelan, Nancy B.;Schneider, Althea M.;Milnes, John T.;Valdivieso, Federico A.;Feldman, Michael;Pass, Harvey I.;Dhir, Rajiv;Melamed, Jonathan;Becich, Michael J.
在转化研究的进步导致需要良好表征的生物标本进行研究。国家间皮瘤虚拟银行是一项倡议，收集与人类间皮瘤相关的注释数据集，以开发一个进取的生物标本资源，以满足研究人员的需求。国家间皮瘤虚拟银行架构基于三个主要组成部分：(a)公共数据元素（基于美国病理学家学院协议和国家北美中心癌症注册协会标准），(b)临床和流行病学数据注释，以及(c)数据查询工具。这些工具可互操作以标准化整个注释过程。国家间皮瘤虚拟银行工具基于caTISSUE临床注释引擎，由匹兹堡大学与癌症生物医学信息网格™（caBIG™，见）合作开发。该应用程序提供了一个基于web的系统，用于注释、导入和搜索间皮瘤病例。底层信息模型是利用统一建模语言类图、层次关系和Enterprise Architect软件构建的。该数据库为研究人员提供了实时访问丰富的注释标本和完整的间皮瘤相关信息。披露的数据受到严格监管，具体取决于用户的授权，以及参与研究的机构是否接受当地机构审查委员会和监管委员会的审查。国家间皮瘤虚拟库目前有超过600个注释病例可供研究人员使用，包括石蜡包埋组织、组织微阵列、血清和基因组DNA。国家间皮瘤虚拟库是一个具有强大的转化生物医学信息学支持的虚拟生物标本注册库，以促进基础科学、临床和转化研究。此外，它通过仅披露未识别的数据集来保护患者隐私，以确保研究人员可以访问生物标本。
Advances in translational research have led to the need for well characterized biospecimens for research. The National Mesothelioma Virtual Bank is an initiative which collects annotated datasets relevant to human mesothelioma to develop an enterprising biospecimen resource to fulfill researchers' need. The National Mesothelioma Virtual Bank architecture is based on three major components: (a) common data elements (based on College of American Pathologists protocol and National North American Association of Central Cancer Registries standards), (b) clinical and epidemiologic data annotation, and (c) data query tools. These tools work interoperably to standardize the entire process of annotation. The National Mesothelioma Virtual Bank tool is based upon the caTISSUE Clinical Annotation Engine, developed by the University of Pittsburgh in cooperation with the Cancer Biomedical Informatics Grid™ (caBIG™, see ). This application provides a web-based system for annotating, importing and searching mesothelioma cases. The underlying information model is constructed utilizing Unified Modeling Language class diagrams, hierarchical relationships and Enterprise Architect software. The database provides researchers real-time access to richly annotated specimens and integral information related to mesothelioma. The data disclosed is tightly regulated depending upon users' authorization and depending on the participating institute that is amenable to the local Institutional Review Board and regulation committee reviews. The National Mesothelioma Virtual Bank currently has over 600 annotated cases available for researchers that include paraffin embedded tissues, tissue microarrays, serum and genomic DNA. The National Mesothelioma Virtual Bank is a virtual biospecimen registry with robust translational biomedical informatics support to facilitate basic science, clinical, and translational research. Furthermore, it protects patient privacy by disclosing only de-identified datasets to assure that biospecimens can be made accessible to researchers.
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