The development of common data elements for a multi-institute prostate cancer tissue bank: the Cooperative Prostate Cancer Tissue Resource (CPCTR) experience.
The development of common data elements for a multi-institute prostate cancer tissue bank: the Cooperative Prostate Cancer Tissue Resource (CPCTR) experience.
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多机构前列腺癌组织库的共同数据元素的发展：合作前列腺癌组织资源（CPCTR）经验。
DOI：
10.1186/1471-2407-5-108
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发表时间：
2005-08-21
期刊：
影响因子：
3.8
通讯作者：
Becich, MJ
中科院分区：
文献类型：
--
作者：
Patel, AA;Kajdacsy-Balla, A;Berman, JJ;Bosland, M;Datta, MW;Dhir, R;Gilbertson, J;Melamed, J;Orenstein, J;Tai, KF;Becich, MJ
合作前列腺癌组织资源（CPCTR）是由美国国家癌症研究所（NCI）资助的四个地理位置分散的机构组成的联盟，旨在为研究人员提供临床注释的前列腺癌组织样本。为了促进这一努力，至关重要的是达成可用于收集人口统计、病理、治疗和临床结果数据的共同数据要素（CDEs）。CPCTR研究人员召集了一个CDE管理小组委员会来开发和实施CDE，用于收集的前列腺组织的注释。cde草案经过了改进和逐步注释，使其符合ISO 11179标准。cde在CPCTR数据库中实现，并使用研究人员开发的软件查询工具进行测试。通过合作共识，CPCTR CDE小组委员会开发了145个数据元素来注释收集的组织样本。这些包括每个病例：1)人口统计数据，2)临床病史，3)病理标本水平元素，用于描述单个手术病理病例的分期，分级和其他特征，4)组织块水平注释，对管理病例虚拟清单和促进病例选择至关重要，5)临床结果数据，包括治疗，复发和生命状态。这些元素已经成功地响应了最终用户对组织的60多个要求，包括5至10年随访病例的石蜡块、组织微阵列（tma）以及用于基因组分析和遗传研究的冷冻组织。CPCTR CDEs已在两个主要组织库中全面实施，并已与数十个其他组织库工作共享。CPCTR开发的免费CDEs基于组织资源的“最佳实践”，并且符合ISO 11179标准。本文中描述的CDE发展过程为其他器官部位提供了框架模型，并已被用作乳腺和黑色素瘤组织库工作的模型。
The Cooperative Prostate Cancer Tissue Resource (CPCTR) is a consortium of four geographically dispersed institutions that are funded by the U.S. National Cancer Institute (NCI) to provide clinically annotated prostate cancer tissue samples to researchers. To facilitate this effort, it was critical to arrive at agreed upon common data elements (CDEs) that could be used to collect demographic, pathologic, treatment and clinical outcome data. The CPCTR investigators convened a CDE curation subcommittee to develop and implement CDEs for the annotation of collected prostate tissues. The draft CDEs were refined and progressively annotated to make them ISO 11179 compliant. The CDEs were implemented in the CPCTR database and tested using software query tools developed by the investigators. By collaborative consensus the CPCTR CDE subcommittee developed 145 data elements to annotate the tissue samples collected. These included for each case: 1) demographic data, 2) clinical history, 3) pathology specimen level elements to describe the staging, grading and other characteristics of individual surgical pathology cases, 4) tissue block level annotation critical to managing a virtual inventory of cases and facilitating case selection, and 5) clinical outcome data including treatment, recurrence and vital status. These elements have been used successfully to respond to over 60 requests by end-users for tissue, including paraffin blocks from cases with 5 to 10 years of follow up, tissue microarrays (TMAs), as well as frozen tissue collected prospectively for genomic profiling and genetic studies. The CPCTR CDEs have been fully implemented in two major tissue banks and have been shared with dozens of other tissue banking efforts. The freely available CDEs developed by the CPCTR are robust, based on "best practices" for tissue resources, and are ISO 11179 compliant. The process for CDE development described in this manuscript provides a framework model for other organ sites and has been used as a model for breast and melanoma tissue banking efforts.
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影响因子：
11.5
作者：
Melamed, J;Datta, MW;Berman, JJ
通讯作者：
Berman, JJ
影响因子：
3
作者：
Berman, JJ;Datta, M;Becich, MJ
通讯作者：
Becich, MJ
影响因子：
3.3
作者：
Berman, JJ
通讯作者：
Berman, JJ
DOI：
10.1016/s1386-5056(03)00005-4
发表时间：
2003-04-01
影响因子：
4.9
作者：
Winget, MD;Baron, JA;Feng, ZD
通讯作者：
Feng, ZD
影响因子：
3.5
作者：
Berman, Jules J;Edgerton, Mary E;Friedman, Bruce A
通讯作者：
Friedman, Bruce A