Mapping correlations between ventricular expansion and CSF amyloid and tau biomarkers in 240 subjects with Alzheimer's disease, mild cognitive impairment and elderly controls.
Mapping correlations between ventricular expansion and CSF amyloid and tau biomarkers in 240 subjects with Alzheimer's disease, mild cognitive impairment and elderly controls.
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DOI：
10.1016/j.neuroimage.2009.02.015
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发表时间：
2009-06
期刊：
影响因子：
5.7
通讯作者：
Thompson, Paul M.
中科院分区：
文献类型：
--
作者：
Chou, Yi-Yu;Lepore, Natasha;Avedissian, Christina;Madsen, Sarah K.;Parikshak, Neelroop;Hua, Xue;Shaw, Leslie M.;Trojanowski, John Q.;Weiner, Michael W.;Toga, Arthur W.;Thompson, Paul M.
使用多图集流体图像对齐的自动心室绘图揭示了阿尔茨海默病的遗传效应，NeuroImage 40(2): 615–630)；通过这种方法，我们计算了检测临床评分和心室图之间的相关性所需的最少受试者数量。我们还评估了阿尔茨海默病病理学的新兴脑脊液生物标志物与阿尔茨海默病神经影像计划的 80 名轻度认知障碍 (MCI) 和 80 名健康对照者的大脑局部缺陷之间的相关性。六个经过专业分割的图像及其嵌入的参数网格表面被流畅地注册到每个大脑；分割在受试者内进行平均以减少错误。基于表面的统计图揭示了表面形态与 4 个变量之间的强大相关性：(1) 诊断，(2) 抑郁严重程度，(3) 基线认知功能，(4) 未来一年的认知能力下降。在基线和 1 年随访时，使用简易精神状态检查 (MMSE)、总体和总和临床痴呆评级 (CDR) 评分来评估认知功能。较低的 CSF Aβ1-42 蛋白水平（AD 病理学的生物标志物，在 240 名受试者中的 138 名中进行评估）与侧心室扩张相关。使用错误发现率 (FDR) 方法，分别需要 40 名和 120 名受试者才能将 AD 和 MCI 与正常组区分开来。需要 120 名受试者来检测心室扩大与 MMSE、总体 CDR、箱总和 CDR 和临床抑郁评分之间的相关性。心室扩张图与 AD 的病理和认知测量相关，并且可能在未来基于成像的临床试验中有用。
Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer’s disease, NeuroImage 40(2): 615–630); with this method, we calculated minimal numbers of subjects needed to detect correlations between clinical scores and ventricular maps. We also assessed correlations between emerging CSF biomarkers of Alzheimer’s disease pathology and localizable deficits in the brain, in 80 AD, 80 mild cognitive impairment (MCI), and 80 healthy controls from the Alzheimer’s Disease Neuroimaging Initiative. Six expertly segmented images and their embedded parametric mesh surfaces were fluidly registered to each brain; segmentations were averaged within subjects to reduce errors. Surface-based statistical maps revealed powerful correlations between surface morphology and 4 variables: (1) diagnosis, (2) depression severity, (3) cognitive function at baseline, and (4) future cognitive decline over the following year. Cognitive function was assessed using the mini-mental state exam (MMSE), global and sum-of-boxes clinical dementia rating (CDR) scores, at baseline and 1-year follow-up. Lower CSF Aβ1–42 protein levels, a biomarker of AD pathology assessed in 138 of the 240 subjects, were correlated with lateral ventricular expansion. Using false discovery rate (FDR) methods, 40 and 120 subjects, respectively, were needed to discriminate AD and MCI from normal groups. 120 subjects were required to detect correlations between ventricular enlargement and MMSE, global CDR, sum-of-boxes CDR and clinical depression scores. Ventricular expansion maps correlate with pathological and cognitive measures in AD, and may be useful in future imaging-based clinical trials.
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影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
3.3
作者：
Ferrarini, Luca;Palm, Walter M.;Admiraal-Behloul, Faiza
通讯作者：
Admiraal-Behloul, Faiza
影响因子：
17.7
作者：
Ballmaier, Martina;Narr, Katherine L.;Kumar, Anand
通讯作者：
Kumar, Anand
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
10.6
作者：
Christensen, GE;Rabbitt, RD;Miller, MI
通讯作者：
Miller, MI