Unraveling the anxious mind: anxiety, worry, and frontal engagement in sustained attention versus off-task processing.
Unraveling the anxious mind: anxiety, worry, and frontal engagement in sustained attention versus off-task processing.
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DOI：
10.1093/cercor/bht248
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Bishop SJ
中科院分区：
文献类型：
--
作者：
Forster S;Nunez Elizalde AO;Castle E;Bishop SJ
关于焦虑、担忧、持续注意力和额叶功能之间的关系，仍有许多未知之处。在这里，我们解决了这一问题，使用持续的注意力任务适用于功能磁共振成像。参与者对简单刺激的呈现做出反应，对不常见的“不去”刺激做出反应。背外侧前额叶皮层（DLPFC）的活动，“去”试验，背前扣带（dACC）的活动，“不去”试验与更快的无错误的性能;一致DLPFC和dACC促进积极主动和反应性控制，分别。特质焦虑与这些区域的招募减少，无差错表现较慢，以及额叶-丘脑-纹状体连接减少有关。这表明特质焦虑和注意力的前额控制能力不足之间存在关联，即使没有外部干扰。在任务块中，委员会的错误，更大的DLPFC楔前叶和DLPFC后扣带回连接与特质焦虑和担心，增加任务外的想法。值得注意的是，与特质焦虑不同，焦虑与额叶-纹状体-丘脑连接性降低、额叶募集不足或在没有委托错误的情况下反应迟缓无关，这与提出焦虑与注意力控制不足之间存在直接因果关系的说法相反。这使我们提出了一个新的模型，焦虑，担心和正面参与注意力控制与任务外思维之间的关系。
Much remains unknown regarding the relationship between anxiety, worry, sustained attention, and frontal function. Here, we addressed this using a sustained attention task adapted for functional magnetic resonance imaging. Participants responded to presentation of simple stimuli, withholding responses to an infrequent “No Go” stimulus. Dorsolateral prefrontal cortex (DLPFC) activity to “Go” trials, and dorsal anterior cingulate (dACC) activity to “No Go” trials were associated with faster error-free performance; consistent with DLPFC and dACC facilitating proactive and reactive control, respectively. Trait anxiety was linked to reduced recruitment of these regions, slower error-free performance, and decreased frontal-thalamo-striatal connectivity. This indicates an association between trait anxiety and impoverished frontal control of attention, even when external distractors are absent. In task blocks where commission errors were made, greater DLPFC-precuneus and DLPFC-posterior cingulate connectivity were associated with both trait anxiety and worry, indicative of increased off-task thought. Notably, unlike trait anxiety, worry was not linked to reduced frontal-striatal-thalamo connectivity, impoverished frontal recruitment, or slowed responding during blocks without commission errors, contrary to accounts proposing a direct causal link between worry and impoverished attentional control. This leads us to propose a new model of the relationship between anxiety, worry and frontal engagement in attentional control versus off-task thought.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
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