Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer.
Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer.
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DOI：
10.1038/s41598-021-92352-3
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发表时间：
2021-06-18
影响因子：
4.6
通讯作者：
Singh AP
中科院分区：
文献类型：
--
作者：
Miree O;Srivastava SK;Khan MA;Sameeta F;Acharya S;Ndetan H;Singh KP;Hertweck KL;Dasgupta S;da Silva LM;Rocconi RP;Carter JE;Singh S;Singh AP
晚期诊断、不可靠的预后评估和指导性较差的治疗计划导致卵巢癌（OC）患者的生存率很低。因此，高度期望鉴定新的功能性生物标志物以改善临床管理。MYB是一种致癌转录因子，在OC中具有新的功能意义。在这里，我们研究了其临床病理意义的免疫组化和TCGA/GTex数据分析。MYB在OC中的异常表达率为94%（n = 373），而在正常卵巢组织中未检测到MYB表达（n = 23）。MYB在所有主要的上皮OC组织学亚型中过表达，在浆液性和粘液性癌中表现出最高的发病率（~ 97%）和总体表达。MYB的表达与肿瘤的分级和分期呈正相关。此外，MYB表现出种族特异性预后相关性。在非裔美国人（AA）中，中至高MYB水平与总体生存率（p = 0.02）和无进展生存率（p = 0.02）均显著相关，但在白人美国人（CA）患者中则不相关。与免疫组化数据一致，我们观察到OC病例（n = 426）中的MYB转录物显著高于正常卵巢（n = 88）。MYB转录显着高于所有上皮OC亚型，与正常相比，其较高的水平预测AA OC，但不是CA OC，患者生存不良。因此，MYB似乎是一种有用的临床生物标志物，特别是在AA患者中。
Late diagnosis, unreliable prognostic assessment, and poorly-guided therapeutic planning result in dismal survival of ovarian cancer (OC) patients. Therefore, identifying novel functional biomarker(s) is highly desired for improved clinical management. MYB is an oncogenic transcription factor with emerging functional significance in OC. Here we examined its clinicopathologic significance by immunohistochemistry and TCGA/GTex data analyses. Aberrant MYB expression was detected in 94% of OC cases (n = 373), but not in the normal ovarian tissues (n = 23). MYB was overexpressed in all major epithelial OC histological subtypes exhibiting the highest incidence (~ 97%) and overall expression in serous and mucinous carcinomas. MYB expression correlated positively with tumor grades and stages. Moreover, MYB exhibited race-specific prognostic association. Moderate-to-high MYB levels were significantly associated with both poor overall- (p = 0.02) and progression-free (p = 0.02) survival in African American (AA), but not in the Caucasian American (CA) patients. Consistent with immunohistochemistry data, we observed significantly higher MYB transcripts in OC cases (n = 426) than normal ovary (n = 88). MYB transcripts were significantly higher in all epithelial OC subtypes, compared to normal, and its greater levels predicted poor survival in AA OC, but not CA OC, patients. Thus, MYB appears to be a useful clinical biomarker for prognostication, especially in AA patients.
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影响因子：
4.7
作者：
Dilley, Sarah;Erickson, Britt K.;Leath, Charles A., III
通讯作者：
Leath, Charles A., III
DOI：
10.1073/pnas.1004640107
发表时间：
2010-10-05
影响因子：
11.1
作者：
Soza-Ried, Cristian;Hess, Isabell;Boehm, Thomas
通讯作者：
Boehm, Thomas
影响因子：
4
作者：
Srivastava SK;Ahmad A;Miree O;Patel GK;Singh S;Rocconi RP;Singh AP
通讯作者：
Singh AP
影响因子：
8
作者：
Tung, Chia-Hao;Kuo, Li-Wei;Hong, Tse-Ming
通讯作者：
Hong, Tse-Ming
影响因子：
4.7
作者：
Srivastava, Sanjeev K.;Bhardwaj, Arun;Singh, Ajay P.
通讯作者：
Singh, Ajay P.