Racial health disparities in ovarian cancer: not just black and white.
Racial health disparities in ovarian cancer: not just black and white.
复制标题
DOI：
10.1186/s13048-017-0355-y
复制
发表时间：
2017-09-21
影响因子：
4
通讯作者：
Singh AP
中科院分区：
文献类型：
--
作者：
Srivastava SK;Ahmad A;Miree O;Patel GK;Singh S;Rocconi RP;Singh AP
卵巢癌（OC）是最致命的妇科恶性肿瘤，不成比例地影响非洲裔美国人（AA）妇女。缺乏认识和社会经济因素被认为是OC种族健康差异的重要因素，而与此同时，最近的一些研究也关注了差异的遗传基础。据报道，不同种族和民族背景的OC患者中存在基因的差异多态性、突变和表达。综合起来，似乎遗传和社会经济因素都不能单独解释OC患者中观察到的种族差异的健康结果。相反，更合理的解释是考虑到这些因素的组合和/或相互作用，甚至可能包括一些环境因素。因此，在这篇文章中，我们试图审查现有的信息OC种族健康差距，并提供一个概述的社会经济，环境和遗传因素，以及表观遗传变化，可以作为三者之间的联系。更好地了解这些根本原因将有助于进一步研究不同患者人群的有效癌症管理，并最终缩小健康差距。
Ovarian cancer (OC) is the most lethal gynecological malignancy, which disproportionately affects African American (AA) women. Lack of awareness and socioeconomic factors are considered important players in OC racial health disparity, while at the same time, some recent studies have brought focus on the genetic basis of disparity as well. Differential polymorphisms, mutations and expressions of genes have been reported in OC patients of diverse racial and ethnic backgrounds. Combined, it appears that neither genetic nor the socioeconomic factors alone might explain the observed racially disparate health outcomes among OC patients. Rather, a more logical explanation would be the one that takes into consideration the combination and/or the interplay of these factors, perhaps even including some environmental ones. Hence, in this article, we attempt to review the available information on OC racial health disparity, and provide an overview of socioeconomic, environmental and genetic factors, as well as the epigenetic changes that can act as a liaison between the three. A better understanding of these underlying causes will help further research on effective cancer management among diverse patient population and ultimately narrow health disparity gaps.
登录
查看更多内容
DOI：
10.1016/j.bbcan.2017.01.001
发表时间：
2017-08
期刊：
Biochimica et biophysica acta. Reviews on cancer
影响因子：
--
作者：
Ahmad A;Azim S;Zubair H;Khan MA;Singh S;Carter JE;Rocconi RP;Singh AP
通讯作者：
Singh AP
影响因子：
5.2
作者：
Allford, Anna;Qureshi, Nadeem;Kai, Joe
通讯作者：
Kai, Joe
影响因子：
6.2
作者：
Farley, John H.;Tian, Chunqiao;Maxwell, G. Larry
通讯作者：
Maxwell, G. Larry
DOI：
10.1007/s10552-016-0806-6
发表时间：
2016-10
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Beckmeyer-Borowko AB;Peterson CE;Brewer KC;Otoo MA;Davis FG;Hoskins KF;Joslin CE
通讯作者：
Joslin CE
DOI：
10.1097/ede.0000000000000528
发表时间：
2016-11
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Gonzalez NL;O'Brien KM;D'Aloisio AA;Sandler DP;Weinberg CR
通讯作者：
Weinberg CR