Down the membrane hole: Ion channels in protozoan parasites.
Down the membrane hole: Ion channels in protozoan parasites.
复制标题
DOI：
10.1371/journal.ppat.1011004
复制
发表时间：
2022-12
期刊：
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
作者：
由原生动物引起的寄生虫病在世界各地高度流行，严重影响发展中国家，在这些国家，与其他微生物的合并感染是常见的。寄生虫感染的控制和治疗受到缺乏特异性和有效药物以及迅速出现耐药性的限制。离子通道是许多疾病的主要药物靶点，但它们对原生动物寄生虫的潜力仍未开发。离子通道是在所有类型的细胞中表达的膜蛋白，允许离子在隔室之间流动，并调节细胞功能，如膜电位、兴奋性、体积、信号传导和死亡。通道和转运蛋白位于寄生虫和宿主之间的界面，控制营养摄取、生存力、复制和感染性。要了解离子通道如何控制原生动物寄生虫的命运，并评估其适用于治疗，我们必须加深我们的知识，他们的结构，功能和调制。然而，通常用于哺乳动物细胞的方法学方法已被证明难以应用于原生动物。这篇评论的重点是在原生动物寄生虫的临床相关性，主要是apicomplexans和锥虫，突出蛋白质的分子和功能的证据已与其生理功能。
Parasitic diseases caused by protozoans are highly prevalent around the world, disproportionally affecting developing countries, where coinfection with other microorganisms is common. Control and treatment of parasitic infections are constrained by the lack of specific and effective drugs, plus the rapid emergence of resistance. Ion channels are main drug targets for numerous diseases, but their potential against protozoan parasites is still untapped. Ion channels are membrane proteins expressed in all types of cells, allowing for the flow of ions between compartments, and regulating cellular functions such as membrane potential, excitability, volume, signaling, and death. Channels and transporters reside at the interface between parasites and their hosts, controlling nutrient uptake, viability, replication, and infectivity. To understand how ion channels control protozoan parasites fate and to evaluate their suitability for therapeutics, we must deepen our knowledge of their structure, function, and modulation. However, methodological approaches commonly used in mammalian cells have proven difficult to apply in protozoans. This review focuses on ion channels described in protozoan parasites of clinical relevance, mainly apicomplexans and trypanosomatids, highlighting proteins for which molecular and functional evidence has been correlated with their physiological functions.
登录
查看更多内容
DOI：
10.1515/acve-2017-0013
发表时间：
2017-06
期刊：
Acta veterinaria
影响因子：
--
作者：
Abongwa M;Martin RJ;Robertson AP
通讯作者：
Robertson AP
影响因子：
13.6
作者：
Balestra AC;Koussis K;Klages N;Howell SA;Flynn HR;Bantscheff M;Pasquarello C;Perrin AJ;Brusini L;Arboit P;Sanz O;Castaño LP;Withers-Martinez C;Hainard A;Ghidelli-Disse S;Snijders AP;Baker DA;Blackman MJ;Brochet M
通讯作者：
Brochet M
DOI：
10.1126/science.1214977
发表时间：
2012-05-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bick AG;Calvo SE;Mootha VK
通讯作者：
Mootha VK
影响因子：
64.8
作者：
Beck, Josh R.;Muralidharan, Vasant;Oksman, Anna;Goldberg, Daniel E.
通讯作者：
Goldberg, Daniel E.
影响因子：
6.4
作者：
Bertolini, Mayara S.;Chiurillo, Miguel A.;Docampo, Roberto
通讯作者：
Docampo, Roberto