Metabolic Syndrome Is Not Associated With Prostate Cancer Recurrence: A Retrospective Analysis of a Chinese Cohort
Metabolic Syndrome Is Not Associated With Prostate Cancer Recurrence: A Retrospective Analysis of a Chinese Cohort
复制标题
代谢综合征与前列腺癌复发无关：对中国队列的回顾性分析
DOI：
10.3389/fonc.2020.00063
复制
发表时间：
2020-01
影响因子：
4.7
通讯作者：
Xie Liping
中科院分区：
文献类型：
--
作者：
Xu Xin;Li Qinchen;Chang Chengdong;Wang Xiao;Xie Liping
目的：代谢综合征（MetS）是一种影响全世界许多人的常见病，已被假设与包括前列腺癌（PCa）在内的人类癌症有关，但这种关联并不一致。本研究的目的是评估met及其成分是否为我院术后前列腺癌生化复发（BCR）的危险因素。材料与方法：本回顾性研究包括214例接受根治性前列腺切除术的前列腺癌患者。使用χ2检验或学生t检验估计组间差异。根据Kaplan-Meier法计算BCR率，采用log-rank检验。采用Cox回归分析进行多因素分析，以确定BCR的显著预测因素。结果：在214名符合条件的男性中，55名经历了BCR， 24名符合MetS诊断标准。多因素Cox模型分析显示，BCR患者Gleason评分较高[风险比（HR） 2.51, 95%可信区间（CI） 1.33-4.76]，神经侵袭阳性（HR 3.57, 95% CI 1.85-6.88）。MetS与BCR无关（HR 0.38, 95% CI 0.13-1.10）。结论：BCR与MetS无关，但与较高的Gleason评分和阳性神经侵袭有关。
Objective: Metabolic syndrome (MetS), a common disease that affects many people around the world, has been hypothesized to be associated with human cancers, including prostate cancer (PCa), but the association has not been consistent. The aim of the current study was to evaluate whether MetS and its components are risk factors for PCa biochemical recurrence (BCR) among a cohort of postoperative patients at our hospital in China. Materials and Methods: This retrospective study included 214 patients with PCa who received radical prostatectomy. Differences between groups were estimated using the χ2 test or Student's t-test. BCR rates were calculated according to the Kaplan-Meier method with the log-rank test. A Cox regression analysis was conducted for the multivariate analyses to identify significant predictors of BCR. Results: Of the 214 eligible men, 55 experienced BCR and 24 met the MetS diagnostic criteria. Multivariate Cox model analysis showed that patients with BCR had a higher Gleason score [hazard ratio (HR) 2.51, 95% confidence interval (CI) 1.33–4.76] and positive nerve invasion (HR 3.57, 95% CI 1.85–6.88). MetS was not associated with BCR (HR 0.38, 95% CI 0.13–1.10). Conclusion: BCR is not associated with MetS but is associated with a higher Gleason score and positive nerve invasion.
登录
查看更多内容
DOI：
10.1016/s0022-5347(05)00388-5
发表时间：
2005-07
期刊：
JAMA
影响因子：
--
作者：
S. Freedland;E. Humphreys;L. Mangold;M. Eisenberger;F. Dorey;P. Walsh;A. Partin
通讯作者：
S. Freedland;E. Humphreys;L. Mangold;M. Eisenberger;F. Dorey;P. Walsh;A. Partin
DOI：
10.1891/9780826121646.0002
发表时间：
2018-09
期刊：
Cancer Rehabilitation
影响因子：
--
作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
通讯作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
影响因子：
3.8
作者：
Fan Zhang;Yuan Yang;L. Skrip;D. Hu;Yang Wang;Chunguang Wong;JingFu Qiu;H. Lei
通讯作者：
Fan Zhang;Yuan Yang;L. Skrip;D. Hu;Yang Wang;Chunguang Wong;JingFu Qiu;H. Lei
影响因子：
5.8
作者：
Lu, Jieli;Wang, Limin;Ning, Guang
通讯作者：
Ning, Guang
影响因子：
8
作者：
Bitzur, Rafael;Brenner, Ronen;Kivity, Shaye
通讯作者：
Kivity, Shaye