Serial position effects in the Logical Memory Test: Loss of primacy predicts amyloid positivity.
Serial position effects in the Logical Memory Test: Loss of primacy predicts amyloid positivity.
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DOI：
10.1111/jnp.12235
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发表时间：
2021-09
影响因子：
2.2
通讯作者：
Johnson SC
中科院分区：
文献类型：
--
作者：
Bruno D;Mueller KD;Betthauser T;Chin N;Engelman CD;Christian B;Koscik RL;Johnson SC
故事回忆是一种在临床人群中经常使用的情景记忆神经心理学测试，也用于阿尔茨海默病药物试验参与者的筛选。然而，在现阶段尚不清楚是哪些潜在机制使该测试具有敏感性。在本文中，我们研究了系列位置效应，即对列表中早期和晚期学习的项目更好的回忆，在故事回忆中的情况，以及它们对预测与神经退行性标记相关的早期变化的有用性。
我们分析了来自威斯康星州阿尔茨海默病预防登记处的数据。首先，我们测试了在被归类为认知未受损 - 稳定、认知未受损 - 下降或患有轻度认知障碍（MCI）的个体中，故事回忆（用韦氏记忆量表逻辑记忆任务；LMT测量）是否存在系列位置效应。
我们的结果显示，除了MCI个体的延迟回忆中未观察到首因效应外，所有组都有明显的系列位置效应。其次，我们测试了在基线时认知未受损的个体中，从即时回忆到延迟回忆首因效应的丧失是否与淀粉样蛋白负荷（用PiB - PET测量）相关。我们发现，更多的首因效应丧失预测了淀粉样蛋白阳性，且超出了LMT总分的影响。
本报告首次表明，即时和延迟故事回忆之间首因效应的丧失与淀粉样蛋白负荷相关。
Story recall is a frequently used neuropsychological test of episodic memory with clinical populations and for screening participants in drug trials for Alzheimer’s disease. However, it is unclear at this stage which underlying mechanisms confer the test its sensitivity. In this paper, we examined serial position effects, i.e., better recall for items learned early and late on a list, in story recall, and their usefulness to predict early changes associated with neurodegenerative markers. We analysed data from the Wisconsin Registry for Alzheimer’s Prevention. First, we tested whether serial position effects were present in story recall (measured with the Wechsler Memory Scale Logical Memory task; LMT) across individuals who were classified as cognitively unimpaired – stable, cognitively unimpaired – declining, or as having mild cognitive impairment (MCI). Our results showed clear serial position effects for all groups, except for delayed recall among individuals with MCI, where no primacy effect was observed. Second, we tested whether loss of primacy from immediate to delayed recall was associated with amyloid burden (as measured with PiB PET) in individuals that were cognitively unimpaired at baseline. We found that more primacy loss predicted amyloid positivity, above and beyond the LMT total score. This report is the first to show that loss of primacy between immediate and delayed story recall is associated with amyloid burden.
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影响因子：
2.4
作者：
Koscik RL;La Rue A;Jonaitis EM;Okonkwo OC;Johnson SC;Bendlin BB;Hermann BP;Sager MA
通讯作者：
Sager MA
DOI：
10.1016/j.nicl.2014.02.001
发表时间：
2014
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Racine AM;Adluru N;Alexander AL;Christian BT;Okonkwo OC;Oh J;Cleary CA;Birdsill A;Hillmer AT;Murali D;Barnhart TE;Gallagher CL;Carlsson CM;Rowley HA;Dowling NM;Asthana S;Sager MA;Bendlin BB;Johnson SC
通讯作者：
Johnson SC
影响因子：
2.4
作者：
Golomb, Julie D.;Peelle, Jonathan E.;Wingfield, Arthur
通讯作者：
Wingfield, Arthur
DOI：
10.3233/jad-160195
发表时间：
2017
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Darst BF;Koscik RL;Racine AM;Oh JM;Krause RA;Carlsson CM;Zetterberg H;Blennow K;Christian BT;Bendlin BB;Okonkwo OC;Hogan KJ;Hermann BP;Sager MA;Asthana S;Johnson SC;Engelman CD
通讯作者：
Engelman CD
影响因子：
--
作者：
MURDOCK, BB
通讯作者：
MURDOCK, BB