Emergence of mild cognitive impairment in late middle-aged adults in the wisconsin registry for Alzheimer's prevention.
Emergence of mild cognitive impairment in late middle-aged adults in the wisconsin registry for Alzheimer's prevention.
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DOI：
10.1159/000355682
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发表时间：
2014
影响因子：
2.4
通讯作者：
Sager MA
中科院分区：
文献类型：
--
作者：
Koscik RL;La Rue A;Jonaitis EM;Okonkwo OC;Johnson SC;Bendlin BB;Hermann BP;Sager MA
可靠地检测与阿尔茨海默病相关的认知障碍的早期迹象是困难的。我们的目的是在一个阿尔茨海默病风险较高的中年纵向队列中比较三种识别遗忘型轻度认知障碍（aMCI）的心理测量方法。
威斯康星州阿尔茨海默病预防登记处（WRAP）的参与者在约6年的时间里接受了3次认知评估，根据三种心理测量的aMCI定义进行编码：a）“aMCI标准 - 基线”使用已公布的标准来确定基线表现的临界值；b）“aMCI稳健 - 基线”将WRAP特定的稳健标准应用于基线；c）“aMCI稳健 - 多波”在3次评估中应用这些稳健标准。将每个组与认知健康的子集进行比较。
在随访中，一半的“aMCI标准 - 基线”组和三分之一的“aMCI稳健 - 基线”组恢复到正常范围。只有“aMCI稳健 - 多波”方法存在aMCI与年龄的相互作用，在6年的随访中，与认知健康组相比，aMCI组显示出与年龄相关的记忆下降明显更严重。
两种横断面方法都显示出随时间的不稳定性，许多人在基线后恢复到正常表现。多波方法确定了一个在3次随访中显示出进行性记忆下降的组。能够检测中年晚期的进行性下降是改进预防工作的关键一步。
It is difficult to detect reliably the earliest signs of Alzheimer's-associated cognitive impairment. Our aim was to compare three psychometric methods of identifying amnestic MCI (aMCI) in a middle-aged longitudinal cohort enriched for AD risk. Wisconsin Registry for Alzheimer's Prevention (WRAP) participants with 3 waves of cognitive assessment over ~6 years were coded as meeting each of three psychometric aMCI definitions: a) ‘aMCI standard-baseline’ used published norms to establish cut-offs for baseline performance; b) ‘aMCI robust-baseline’ applied WRAP-specific robust norms to baseline; and c) ‘aMCI robust-multiwave’ applied these robust norms across 3 waves of assessment. Each group was compared to a cognitively healthy subset. Half the aMCI standard-baseline and one-third the aMCI robust-baseline group reverted to normal ranges at follow-up. Only the aMCI robust-multiwave method had an aMCI*age interaction showing significantly worse age-related memory declines in the aMCI group compared to the cognitively healthy group over six years of follow-up. Both cross-sectional methods showed instability over time, with many reverting to normal performance post-baseline. The multiwave approach identified a group who showed progressive memory declines over 3 visits. Being able to detect progressive decline in late-middle-age is a critical step in improving prevention efforts.
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DOI：
10.1176/appi.ajp.2010.09111575
发表时间：
2010-11
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Donix M;Burggren AC;Suthana NA;Siddarth P;Ekstrom AD;Krupa AK;Jones M;Martin-Harris L;Ercoli LM;Miller KJ;Small GW;Bookheimer SY
通讯作者：
Bookheimer SY
影响因子：
7
作者：
Duff, Kevin;Beglinger, Leigh J.;Paulsen, Jane S.
通讯作者：
Paulsen, Jane S.
影响因子：
2.4
作者：
De Santi, Susan;Pirraglia, Elizabeth;Reisberg, Barry
通讯作者：
Reisberg, Barry
影响因子：
2.4
作者：
Cherbuin, Nicolas;Reglade-Meslin, Chantal;Anstey, Kaarin J.
通讯作者：
Anstey, Kaarin J.
DOI：
10.1076/jcen.24.6.720.8397
发表时间：
2002-09-01
影响因子：
2.2
作者：
Collie, A;Maruff, P;Currie, J
通讯作者：
Currie, J