The checkpoint for agonist selection precedes conventional selection in human thymus.
The checkpoint for agonist selection precedes conventional selection in human thymus.
复制标题
激动剂选择的检查点先于人胸腺的常规选择。
DOI：
10.1126/sciimmunol.aah4232
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发表时间：
2017-02-24
影响因子：
24.8
通讯作者：
Vandekerckhove B
中科院分区：
文献类型：
--
作者：
Verstichel G;Vermijlen D;Martens L;Goetgeluk G;Brouwer M;Thiault N;Van Caeneghem Y;De Munter S;Weening K;Bonte S;Leclercq G;Taghon T;Kerre T;Saeys Y;Van Dorpe J;Cheroutre H;Vandekerckhove B
The thymus plays a central role in self-tolerance, in part by eliminating precursors with a T cell receptor (TCR) that binds strongly to self-antigens. However, the generation of self-agonist-selected lineages also relies on strong TCR signaling. How thymocytes discriminate between these opposite outcomes remains elusive. Here we identified a human agonist-selected PD-1+ CD8αα+ subset of mature CD8αβ+ T cells that displays an effector phenotype associated with agonist selection. Interestingly, TCR stimulation of immature post-β-selection thymocyte blasts specifically gives rise to this innate subset and fixes early TRAV and TRAJ rearrangements in the TCR repertoire. These findings suggest that the checkpoint for agonist selection precedes conventional selection in human thymus.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
20.3
作者：
Kisielow, Jan;Tortola, Luigi;Kopf, Manfred
通讯作者：
Kopf, Manfred
影响因子：
4.4
作者：
Hendricks, Deborah W.;Fink, Pamela J.
通讯作者：
Fink, Pamela J.
影响因子：
32.4
作者：
Jones, Mary Elizabeth;Zhuang, Yuan
通讯作者：
Zhuang, Yuan
影响因子：
3.6
作者：
Getnet D;Grosso JF;Goldberg MV;Harris TJ;Yen HR;Bruno TC;Durham NM;Hipkiss EL;Pyle KJ;Wada S;Pan F;Pardoll DM;Drake CG
通讯作者：
Drake CG