Consumption of Hypoallergenic Flour Prevents Gluten-induced Airway Inflammation in Brown Norway Rats
Consumption of Hypoallergenic Flour Prevents Gluten-induced Airway Inflammation in Brown Norway Rats
复制标题
食用低过敏性面粉可预防棕色挪威大鼠麸质引起的气道炎症
DOI：
10.1271/bbb.65.1729
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
K. Sonoyama
中科院分区：
文献类型：
--
作者：
J. Watanabe;S. Tanabe;M. Watanabe;T. Kasai;K. Sonoyama
用麸质免疫Brown Norway大鼠，然后喂食含有低过敏性氟或氨基酸混合物的饮食。然后让大鼠吸入溶解的麸质，以诱导麸质特异性支气管哮喘。ELISA法测定血清抗体水平，支气管肺泡灌洗液细胞涂片计数。在喂食氨基酸混合物的大鼠中，过敏原攻击后体重下降，但在喂食低变应原面粉的大鼠中则没有。在血清中的抗体水平显着低于低过敏性面粉喂养的大鼠比那些喂养的氨基酸混合物。支气管肺泡灌洗液中的细胞分类计数显示，喂食低变应原面粉的大鼠中嗜酸性粒细胞、淋巴细胞和中性粒细胞的数量显著低于喂食氨基酸混合物的大鼠。这些结果表明，低过敏性面粉积极抑制过敏反应，可能是通过诱导口服耐受。
Brown Norway rats were immunized with gluten, and then fed a diet containing hypoallergenic fluor or an amino acid mixture. The rats were then made to inhale a solubilized gluten to induce gluten-specific bronchial asthma. The antibody levels in the serum of rats were measured by ELISA, and cell counts were done on cytospin preparations of bronchoalveolar lavage fluid. Body weight was decreased after allergen challenge in rats fed the amino acid mixture but not in rats fed the hypoallergenic flour. Antibody levels in the serum were significantly lower in rats fed hypoallergenic flour than in those fed the amino acid mixture. Differential cell counts in the bronchoalveolar lavage fluid showed that the numbers of eosinophils, lymphocytes, and neutrophils were significantly lower in rats fed the hypoallergenic flour than in those fed the amino acid mixture. These results suggest that hypoallergenic flour actively suppresses the allergic reactions, probably by inducing oral tolerance.
影响因子：
4.4
作者：
T. Mosmann;H. Cherwinski;M. Bond;M. Giedlin;R. Coffman
通讯作者：
T. Mosmann;H. Cherwinski;M. Bond;M. Giedlin;R. Coffman