Heavier smoking increases coffee consumption: findings from a Mendelian randomization analysis.
Heavier smoking increases coffee consumption: findings from a Mendelian randomization analysis.
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DOI：
10.1093/ije/dyx147
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发表时间：
2017-12-01
影响因子：
7.7
通讯作者：
Davey Smith G
中科院分区：
文献类型：
--
作者：
Bjørngaard JH;Nordestgaard AT;Taylor AE;Treur JL;Gabrielsen ME;Munafò MR;Nordestgaard BG;Åsvold BO;Romundstad P;Davey Smith G
有证据表明，吸烟者的香烟和咖啡消费量之间存在积极的关系。香烟烟雾会增加咖啡因的新陈代谢，因此这可能代表了吸烟对咖啡因摄入量的因果影响。我们在英国生物库(N=114029)、挪威狩猎研究(N=56664)和哥本哈根一般人口研究(CGPS)(N=78650)中进行了孟德尔随机分析。在所有研究中，我们使用rs16969968基因变异作为吸烟严重程度的替代指标，在英国生物库和CGPS中使用rs4410790和rs2472297作为咖啡消费的替代指标。分析使用线性回归和荟萃分析跨研究进行。当前吸烟者每天每多吸一支烟，咖啡的消费量就会增加(0.10杯/天，95%可信区间：0.03，0.17)。每天每多吸一支烟，饮茶量增加的证据很弱(每天0.04杯，95%CI：−0.002，0.07)。有强有力的证据表明，在当前吸烟者中，rs16969968微小等位基因每增加一个副本(增加每天吸烟)与较高的咖啡消费量(每天0.16杯，95%可信区间：0.11，0.20)相关，但与喝茶(每天0.04杯，95%可信区间：-0.01，0.09)相关的证据很弱。没有明确的证据表明rs16969968与从未吸烟者或曾经吸烟者喝咖啡或茶有关，或者与咖啡相关的变异与吸烟有关。更高的香烟消费量必然会增加咖啡的摄入量。这与吸烟者对咖啡因的快速新陈代谢是一致的，但也可能反映了吸烟对喝咖啡的行为影响。
There is evidence for a positive relationship between cigarette and coffee consumption in smokers. Cigarette smoke increases metabolism of caffeine, so this may represent a causal effect of smoking on caffeine intake. We performed Mendelian randomization analyses in the UK Biobank (N = 114 029), the Norwegian HUNT study (N = 56 664) and the Copenhagen General Population Study (CGPS) (N = 78 650). We used the rs16969968 genetic variant as a proxy for smoking heaviness in all studies and rs4410790 and rs2472297 as proxies for coffee consumption in UK Biobank and CGPS. Analyses were conducted using linear regression and meta-analysed across studies. Each additional cigarette per day consumed by current smokers was associated with higher coffee consumption (0.10 cups per day, 95% CI: 0.03, 0.17). There was weak evidence for an increase in tea consumption per additional cigarette smoked per day (0.04 cups per day, 95% CI: −0.002, 0.07). There was strong evidence that each additional copy of the minor allele of rs16969968 (which increases daily cigarette consumption) in current smokers was associated with higher coffee consumption (0.16 cups per day, 95% CI: 0.11, 0.20), but only weak evidence for an association with tea consumption (0.04 cups per day, 95% CI: -0.01, 0.09). There was no clear evidence that rs16969968 was associated with coffee or tea consumption in never or former smokers or that the coffee-related variants were associated with cigarette consumption. Higher cigarette consumption causally increases coffee intake. This is consistent with faster metabolism of caffeine by smokers, but could also reflect a behavioural effect of smoking on coffee drinking.
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影响因子：
6.4
作者：
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通讯作者：
Sinha, Rashmi
影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
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在15q25染色体上的遗传变异与烟草暴露的客观度量之间的关联。
DOI：
10.1093/jnci/djs191
发表时间：
2012-05-16
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Munafò MR;Timofeeva MN;Morris RW;Prieto-Merino D;Sattar N;Brennan P;Johnstone EC;Relton C;Johnson PC;Walther D;Whincup PH;Casas JP;Uhl GR;Vineis P;Padmanabhan S;Jefferis BJ;Amuzu A;Riboli E;Upton MN;Aveyard P;Ebrahim S;Hingorani AD;Watt G;Palmer TM;Timpson NJ;EPIC Study Group;Davey Smith G
通讯作者：
Davey Smith G