Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
复制标题
全基因组关联荟萃分析发现了与东亚人空腹血糖相关的新变异。
作者：
Hwang JY;Sim X;Wu Y;Liang J;Tabara Y;Hu C;Hara K;Tam CH;Cai Q;Zhao Q;Jee S;Takeuchi F;Go MJ;Ong RT;Ohkubo T;Kim YJ;Zhang R;Yamauchi T;So WY;Long J;Gu D;Lee NR;Kim S;Katsuya T;Oh JH;Liu J;Umemura S;Kim YJ;Jiang F;Maeda S;Chan JC;Lu W;Hixson JE;Adair LS;Jung KJ;Nabika T;Bae JB;Lee MH;Seielstad M;Young TL;Teo YY;Kita Y;Takashima N;Osawa H;Lee SH;Shin MH;Shin DH;Choi BY;Shi J;Gao YT;Xiang YB;Zheng W;Kato N;Yoon M;He J;Shu XO;Ma RC;Kadowaki T;Jia W;Miki T;Qi L;Tai ES;Mohlke KL;Han BG;Cho YS;Kim BJ
空腹血糖（FPG）已被认为是代谢性疾病发作前总体血糖状态的重要指标。到目前为止，大多数已确定的FPG全基因组关联位点来自欧洲血统的人群，只有少数例外。为了扩展FPG基因座的完整目录，我们对多达24，740名东亚血统的非糖尿病受试者进行了13项全基因组关联研究的荟萃分析。在另外21，345名参与者中进行的随访复制分析确定了三个新的FPG基因座，这些基因座在PDK 1-RAPGEF 4，KANK 1和IGF 1 R中或附近达到全基因组意义。我们的研究结果可以为空腹血糖调节中涉及的遗传变异提供额外的见解。
Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
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全基因组关联研究的荟萃分析确定了东亚人 2 型糖尿病的 8 个新位点
影响因子：
30.8
作者：
Cho, Yoon Shin;Chen, Chien-Hsiun;Hu, Cheng;Long, Jirong;Ong, Rick Twee Hee;Sim, Xueling;Takeuchi, Fumihiko;Wu, Ying;Go, Min Jin;Yamauchi, Toshimasa;Chang, Yi-Cheng;Kwak, Soo Heon;Ma, Ronald C. W.;Yamamoto, Ken;Adair, Linda S.;Aung, Tin;Cai, Qiuyin;Chang, Li-Ching;Chen, Yuan-Tsong;Gao, Yutang;Hu, Frank B.;Kim, Hyung-Lae;Kim, Sangsoo;Kim, Young Jin;Lee, Jeannette Jen-Mai;Lee, Nanette R.;Li, Yun;Liu, Jian Jun;Lu, Wei;Nakamura, Jiro;Nakashima, Eitaro;Ng, Daniel Peng-Keat;Tay, Wan Ting;Tsai, Fuu-Jen;Wong, Tien Yin;Yokota, Mitsuhiro;Zheng, Wei;Zhang, Rong;Wang, Congrong;So, Wing Yee;Ohnaka, Keizo;Ikegami, Hiroshi;Hara, Kazuo;Cho, Young Min;Cho, Nam H.;Chang, Tien-Jyun;Bao, Yuqian;Hedman, Asa K.;Morris, Andrew P.;McCarthy, Mark I.;Takayanagi, Ryoichi;Park, Kyong Soo;Jia, Weiping;Chuang, Lee-Ming;Chan, Juliana C. N.;Maeda, Shiro;Kadowaki, Takashi;Lee, Jong-Young;Wu, Jer-Yuarn;Teo, Yik Ying;Tai, E. Shyong;Shu, Xiao Ou;Mohlke, Karen L.;Kato, Norihiro;Han, Bok-Ghee;Seielstad, Mark
通讯作者：
Seielstad, Mark
影响因子：
4.9
作者：
Sookoian, Silvia;Fernandez Gianotti, Tomas;Pirola, Carlos J.
通讯作者：
Pirola, Carlos J.
影响因子：
3.9
作者：
Riedemann, J.;Macaulay, V. M.
通讯作者：
Macaulay, V. M.
新的遗传基因座涉及禁食葡萄糖稳态及其对2型糖尿病风险的影响。
影响因子：
30.8
作者：
通讯作者：
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影响因子：
--
作者：
Tabangin ME;Woo JG;Martin LJ
通讯作者：
Martin LJ