The GSDMB rs7216389 SNP is associated with chronic rhinosinusitis in a multi-institutional cohort.
The GSDMB rs7216389 SNP is associated with chronic rhinosinusitis in a multi-institutional cohort.
复制标题
DOI：
10.1002/alr.22824
复制
发表时间：
2021-12
影响因子：
6.4
通讯作者：
Chang EH
中科院分区：
文献类型：
--
作者：
Zack DE;Stern DA;Willis AL;Kim AS;Mansfield CJ;Reed DR;Brooks SG;Adappa ND;Palmer JN;Cohen NA;Chiu AG;Song BH;Le CH;Chang EH
慢性鼻窦炎（CRS）是一种多因素疾病，极易与哮喘共发。在这项多队列研究中，我们在一项多队列回顾性病例对照研究中测试了与儿童哮喘和鼻病毒相关疾病相关的单核苷酸多态性（snp）是否增加了成人CRS的易感性。研究人员招募了亚利桑那大学（UofA）和宾夕法尼亚大学（UPenn）两所高等学术鼻科中心的参与者。病例定义为医生诊断的CRS患者（UofA n=149, UPenn n=250），健康对照组为无CRS患者（UofA n=66, UPenn n=275）。基因组DNA筛选GSDMB rs7216389 SNP和CDHR3 rs6967330 SNP。计算基因剂量，或单个受试者中组合风险等位基因的数量。对GSDMB或CDHR3基因型与CRS之间的相关性进行meta分析，并使用p趋势计算每个人群的加性基因剂量效应。荟萃分析显示，具有GSDMB rs7216389 SNP的受试者发生CRS的风险增加（OR=1.40, 95%CI:1.16, 1.76, p=0.004）。UofA人群（OR=1.73, 95%CI:1.23, 2.43, p=0.002）和UPenn人群（OR=1.27, 95%CI:1.02, 1.58, p=0.035）显示GSDMB rs7216389 SNP和CDHR3 rs6967330 SNP组合风险等位基因数量与CRS风险呈显著正相关。GSDMB rs7216389 SNP和CDHR3 rs6967330 SNP的携带者对CRS的易感性增加。这些数据表明，针对RV感染异常反应的治疗方法可能在统一气道疾病的治疗中发挥作用。
Chronic rhinosinusitis (CRS) is a multifactorial disease with a high co-occurrence with asthma. In this multi-cohort study, we test if single nucleotide polymorphisms (SNPs) associated with childhood asthma and rhinovirus-associated disease have an increased susceptibility to adult CRS in a multi-cohort retrospective case-control study. Participants at two tertiary academic rhinology centers, University of Arizona (UofA) and University of Pennsylvania (UPenn) were recruited. Cases were defined as those with physician diagnosed CRS (UofA n=149, UPenn n=250), and healthy controls were those without CRS (UofA n=66, UPenn n=275). Genomic DNA was screened for the GSDMB rs7216389 SNP and CDHR3 rs6967330 SNP. Gene dosage, or the number of combined risk alleles in a single subject was calculated. Meta-analysis of the association between GSDMB or CDHR3 genotypes and CRS was performed and additive gene dosage effect for each population calculated using a p-trend. A meta-analysis revealed a combined increased risk for CRS in subjects with the GSDMB rs7216389 SNP (OR=1.40, 95%CI:1.16, 1.76, p=0.004). Both the UofA (OR=1.73, 95%CI:1.23, 2.43, p=0.002) and UPenn (OR=1.27, 95%CI:1.02, 1.58, p=0.035) populations showed a significant positive association between the number of combined risk alleles of GSDMB rs7216389 SNP and CDHR3 rs6967330 SNP and risk for CRS. Carriers of the GSDMB rs7216389 SNP and CDHR3 rs6967330 SNP are at increased susceptibility for CRS. This data suggest that therapeutic approaches to target aberrant responses to RV infection may play a role in the treatment of unified airway disease.
登录
查看更多内容
影响因子：
158.5
作者：
Bouzigon, Emmanuelle;Corda, Eve;Demenais, Florence
通讯作者：
Demenais, Florence
影响因子：
30.8
作者：
Bonnelykke, Klaus;Sleiman, Patrick;Bisgaard, Hans
通讯作者：
Bisgaard, Hans
DOI：
10.1165/rcmb.2018-0220oc
发表时间：
2019-10-01
影响因子：
6.4
作者：
Basnet, Sarmila;Bochkov, Yury A.;Gern, James E.
通讯作者：
Gern, James E.
影响因子：
9.8
作者：
Verlaan, Dominique J.;Berlivet, Soizik;Naumova, Anna K.
通讯作者：
Naumova, Anna K.
DOI：
10.1073/pnas.1610433113
发表时间：
2016-11-15
影响因子：
11.1
作者：
Das, Sudipta;Miller, Marina;Broide, David H.
通讯作者：
Broide, David H.