Nucleocytoplasmic partitioning as a mechanism to regulate Arabidopsis signaling events.
Nucleocytoplasmic partitioning as a mechanism to regulate Arabidopsis signaling events.
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DOI：
10.1016/j.ceb.2021.01.006
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发表时间：
2021-04
影响因子：
7.5
通讯作者：
Strader LC
中科院分区：
文献类型：
--
作者：
Allen JR;Strader LC
细胞核是转录事件发生的场所-真核生物中转录的区室化允许调控进入染色质。核孔是许多内在紊乱蛋白的复合物，充当核进入和离开的看门人，并且核定位信号（NLS）和核输出信号（NES）的受体与货物和核孔组分相互作用以促进这种运动。因此，NLS或内斯的受调节的闭塞、蛋白质的束缚或生物分子缩合物中的螯合可用于调节核质分配。在植物中，受调节的核质分配是调节信号传导途径的关键机制，包括参与各种植物激素、环境刺激和病原体反应的信号传导途径。
The nucleus is the site of transcription events - compartmentalization of transcription in eukaryotes allows for regulated access to chromatin. The nucleopore, a complex of many intrinsically disorder proteins, acts as the gatekeeper for nuclear entry and exit and receptors for Nuclear Localization Signals (NLSs) and Nuclear Export Signals (NESs) interact with both cargo and nucleopore components to facilitate this movement. Thus, regulated occlusion of the NLS or NES, tethering of proteins or sequestration in biomolecular condensates can be used to regulate nucleo-cytoplasmic partitioning. In plants, regulated nucleo-cytoplasmic partitioning is a key mechanism to regulate signaling pathways, including those involved in various phytohormone, environmental stimuli, and pathogen responses.
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影响因子：
4.5
作者：
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