Effect of altered arterial perfusion pressure on vascular conductance and muscle blood flow dynamic response during exercise in humans.
Effect of altered arterial perfusion pressure on vascular conductance and muscle blood flow dynamic response during exercise in humans.
复制标题
动脉灌注压改变对人体运动过程中血管电导和肌肉血流动态反应的影响。
DOI：
10.1152/japplphysiol.01094.2012
复制
发表时间：
2013
影响因子：
3.3
通讯作者：
R. Hughson
中科院分区：
文献类型：
--
作者：
R. Villar;R. Hughson
在运动过程中，需要改变血管电导(VC)来对抗肌肉灌注压(MPP)的变化，以维持肌肉血流量(MBF)。我们研究了在两种不同工作速率下三个体位测量的VC峰值对VC招募的影响，以检验在VC中的适应补偿了低功率输出(LPO)时MPP的变化，而不是高功率输出(HPO)时的MPP变化。11名健康志愿者分别进行水平(HOR)、35°头低位(HDT)和45°头高位(HUT)的LPO和HPO(重复足底屈曲收缩，最大自主收缩幅度分别为20-30%)训练。超声测量肌肉血流速度和月国窝径以确定MBF，用MBF流量除以MPP计算VC。Vc峰值不受体位影响。HUT组MBF和VC增加速度明显快于HOR组，而HDT组慢于HOR组，LPO组较HPO组快。在LPO运动中，HUT和HDT的MBF增加和稳定期值小于HOR；VC的增加HUT小于HOR和HDT。在HPO运动中，尽管Vc达到92%的峰值，但HDT组的MBF仍低于HOR和HUT，后者大于HOR，而HUT则大于HUT。HPO-HDT运动中MBF减少的功能结果是肌肉肌电指数显著增加，揭示了MPP对运动过程中氧气输送的影响。
Changes in vascular conductance (VC) are required to counter changes in muscle perfusion pressure (MPP) to maintain muscle blood flow (MBF) during exercise. We investigated the recruitment of VC as a function of peak VC measured in three body positions at two different work rates to test the hypothesis that adaptations in VC compensated changes in MPP at low-power output (LPO), but not at high-power output (HPO). Eleven healthy volunteers exercised at LPO and HPO (repeated plantar flexion contractions at 20-30% maximal voluntary contraction, respectively) in horizontal (HOR), 35° head-down tilt (HDT), and 45° head-up tilt (HUT). Muscle blood flow velocity and popliteal diameter were measured by ultrasound to determine MBF, and VC was estimated by dividing MBF flow by MPP. Peak VC was unaffected by body position. The rates of increase in MBF and VC were significantly faster in HUT and slower in HDT than HOR, and rates were faster in LPO than HPO. During LPO exercise, the increase in, and steady-state values of, MBF were less for HUT and HDT than HOR; the increase in VC was less in HUT than HOR and HDT. During HPO exercise, MBF in the HDT was reduced compared with HOR and HUT, even though VC reached 92% VC peak, which was greater than HOR, which was, in turn, greater than HUT. Reduced MBF during HPO HDT exercise had the functional consequence of a significant increase in muscle electromyographic index, revealing the effects of MPP on O2 delivery during exercise.
抬头倾斜期间灌注压对血管阻力反应的贡献。
DOI：
10.1152/ajpheart.2001.281.1.h371
发表时间：
2001
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Imadojemu,VA;Lott,ME;Gleeson,K;Hogeman,CS;Ray,CA;Sinoway,LI
通讯作者：
Sinoway,LI
乙酰胆碱和一氧化氮对运动开始和恢复时前臂血流的贡献。
DOI：
10.1152/ajpheart.1997.273.5.h2388
发表时间：
1997
期刊：
The American journal of physiology
影响因子：
--
作者：
Shoemaker,JK;Halliwill,JR;Hughson,RL;Joyner,MJ
通讯作者：
Joyner,MJ
一氧化氮合酶抑制不会影响抬头倾斜期间肌肉交感神经活动的调节。
DOI：
10.1152/ajpheart.01076.2002
发表时间：
2003
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Cui,Jian;Zhang,Rong;Wilson,ThadE;Witkowski,Sarah;Crandall,CraigG;Levine,BenjaminD
通讯作者：
Levine,BenjaminD