RNA polymerase II stalling: loading at the start prepares genes for a sprint.

RNA polymerase II stalling: loading at the start prepares genes for a sprint.
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DOI:
10.1186/gb-2008-9-5-220
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发表时间:
2008
期刊:
影响因子:
12.3
通讯作者:
Snyder M
Snyder M
中科院分区:
生物学1区
文献类型:
--
作者:
Wu JQ;Snyder M

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启动子-近端聚合酶II停滞使基因准备好在收到信号后迅速表达。最近发现,RNA聚合酶II在启动子附近的停滞比之前认为的要普遍得多。对这一现象的全基因组调查表明,这很可能是对基因激活的限速控制,当收到诱导信号时,平衡发育和刺激反应基因,以便迅速表达。
Promoter-proximal polymerase II stalling prepares genes for prompt expression when signals are received. Stalling of RNA polymerase II near the promoter has recently been found to be much more common than previously thought. Genome-wide surveys of the phenomenon suggest that it is likely to be a rate-limiting control on gene activation that poises developmental and stimulus-responsive genes for prompt expression when inducing signals are received.
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