Polydendrocytes in development and myelin repair.

Polydendrocytes in development and myelin repair.
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DOI:
10.1007/s12264-013-1320-4
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发表时间:
2013-04
影响因子:
5.6
通讯作者:
Nishiyama, Akiko
Nishiyama, Akiko
中科院分区:
医学2区
文献类型:
--
作者:
Zuo, Hao;Nishiyama, Akiko

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多突胶质细胞(NG2细胞)是一种独特类型的神经胶质细胞,分布于发育和成年中枢神经系统(CNS)。在成人中枢神经系统中,它们保留有丝分裂活性,代表最大的增殖细胞群。遗传和表观遗传机制调节多突胶质细胞的命运,从而产生少突胶质细胞和星形胶质细胞。此外,多突胶质细胞主动分化成髓鞘形成的少突胶质细胞,以响应脱髓鞘。本文综述了目前有关多突胶质细胞发育的知识,为了解脱髓鞘病变髓鞘再生的机制提供了重要依据。
Polydendrocytes (NG2 cells) are a distinct type of glia that populate the developing and adult central nervous systems (CNS). In the adult CNS, they retain mitotic activity and represent the largest proliferating cell population. Genetic and epigenetic mechanisms regulate the fate of polydendrocytes, which give rise to both oligodendrocytes and astrocytes. In addition, polydendrocytes actively differentiate into myelin-forming oligodendrocytes in response to demyelination. This review summarizes the current knowledge regarding polydendrocyte development, which provides an important basis for understanding the mechanisms that lead to the remyelination of demyelinated lesions.
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