Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells.
Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells.
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(-)-表没食子儿茶素-3-没食子酸酯在 LNCaP 前列腺癌细胞不同进展阶段抑制雄激素受体信号传导和前列腺特异性抗原表达。
DOI：
10.1016/j.canlet.2008.10.001
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发表时间：
2009-03-08
期刊：
影响因子：
9.7
通讯作者：
Liao, Shutsung
中科院分区：
文献类型：
--
作者：
Chuu, Chih-Pin;Chen, Rou-Yu;Kokontis, John M.;Hiipakka, Richard A.;Liao, Shutsung
The green tea polyphenol, (−)-epigallocatechin-3-gallate (EGCG), inhibits the development and progression of prostate cancer in TRAMP mice and in men. We examined the effects of EGCG on LNCaP human prostate cancer sublines 104-S, 104-R1 and R1Ad representing different progression stages of prostate cancer. EGCG suppressed cell proliferation, prostate specific antigen (PSA) expression, and AR transcriptional activity in the different LNCaP sublines. Intraperitoneal administration of EGCG also suppressed the growth of relapsing R1Ad tumors and decreased tumor-derived serum PSA. Effects of EGCG on tumor PSA expression have the potential to affect accurate monitoring of patient tumor burden by serum PSA measurements.
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影响因子：
4.7
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Siddiqui, IA;Zaman, N;Mukhtar, H
通讯作者：
Mukhtar, H
影响因子：
3.9
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Gupta, S;Hussain, T;Mukhtar, H
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Mukhtar, H
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9.7
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LIAO, SS;UMEKITA, Y;HIIPAKKA, RA
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HIIPAKKA, RA
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4.8
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Cleutjens, KBJM;vanEekelen, CCEM;Trapman, J
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Trapman, J
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3.8
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Gupta, S;Ahmad, N;Mukhtar, H
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Mukhtar, H