Asymmetric Complexity in a Pupil Control Model With Laterally Imbalanced Neural Activity in the Locus Coeruleus: A Potential Biomarker for Attention-Deficit/Hyperactivity Disorder
Asymmetric Complexity in a Pupil Control Model With Laterally Imbalanced Neural Activity in the Locus Coeruleus: A Potential Biomarker for Attention-Deficit/Hyperactivity Disorder
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蓝斑神经活动横向不平衡的瞳孔控制模型中的不对称复杂性：注意力缺陷/多动症的潜在生物标志物
DOI：
10.1162/neco_a_01545
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发表时间：
2022
影响因子：
2.9
通讯作者：
Shigenobu Toda
中科院分区：
文献类型：
--
作者：
Hiraku Kumano;Sou Nobukawa;Aya Shirama;Tetsuya Takahashi;Toshinobu Takeda;Ohta Haruhisa;Mitsuru Kikuchi;Akira Iwanami;Nobumasa Kato;Shigenobu Toda
蓝斑（LC）过度活跃，特别是在右半球，是公认的注意力缺陷/多动障碍（ADHD）的病理生理学，可能与注意力不集中有关。LC活动与瞳孔直径的动力学一致，并反映与认知功能（如注意和唤醒）相关的神经活动。最近的研究强调瞳孔直径的时间模式的复杂性的重要性。此外，不对称的瞳孔直径，这与注意力不集中，冲动，多动症的严重程度，可能是由于左，右LC活动的不平衡。我们最近构建了一个计算模型的瞳孔直径的基础上，新发现的对侧投影从LC的Edinger-Westphal核（EWN），这表明瞳孔动力学的复杂的时间模式的机制;然而，它仍然不清楚如何LC过度活跃及其不对称性影响瞳孔直径。我们假设，瞳孔直径控制的神经模型具有左右LC活动的差异和对两侧的投射，可能会澄清瞳孔行为在ADHD研究中的作用。因此，我们开发了一个瞳孔直径控制模型，反映了LC过度活跃在右半球，通过将对侧投影从LC到EWN和评估的模型所产生的瞳孔直径的时间模式的复杂性。在与ADHD成人患者中实验测量的瞳孔直径进行比较后，估计神经模型的感兴趣的参数区域，这是复杂性与左侧LC基线活动和右侧LC基线活动的二维图中的区域。一个区域导致相对较高的右侧的复杂性，这对应于病理生理指标，被确定。我们预计，瞳孔直径波动的复杂性偏侧化的发现将有助于准确诊断ADHD的生物标志物的发展。
Locus coeruleus (LC) overactivity, especially in the right hemisphere, is a recognized pathophysiology of attention-deficit/hyperactivity disorder (ADHD) and may be related to inattention. LC activity synchronizes with the kinetics of the pupil diameter and reflects neural activity related to cognitive functions such as attention and arousal. Recent studies highlight the importance of the complexity of the temporal patterns of pupil diameter. Moreover, asymmetrical pupil diameter, which correlates with the severity of inattention, impulsivity, and hyperactivity in ADHD, might be attributed to a left-right imbalance in LC activity. We recently constructed a computational model of pupil diameter based on the newly discovered contralateral projection from the LC to the Edinger–Westphal nucleus (EWN), which demonstrated mechanisms for the complex temporal patterns of pupil kinetics; however, it remains unclear how LC overactivity and its asymmetry affect pupil diameter. We hypothesized that a neural model of pupil diameter control featuring left-right differences in LC activity and projections onto two opponent sides may clarify the role of pupil behavior in ADHD studies. Therefore, we developed a pupil diameter control model reflecting LC overactivity in the right hemisphere by incorporating a contralateral projection from the LC to EWN and evaluated the complexity of the temporal patterns of pupil diameter generated by the model. Upon comparisons with experimentally measured pupil diameters in adult patients with ADHD, the parameter region of interest of the neural model was estimated, which was a region in the two-dimensional plot of complexity versus left-side LC baseline activity and that of the right. A region resulting in relatively high right-side complexity, which corresponded to the pathophysiological indexes, was identified. We anticipate that the discovery of lateralization of complexity in pupil diameter fluctuations will facilitate the development of biomarkers for accurate diagnosis of ADHD.
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影响因子：
5.7
作者：
Elena Makovac;S. Fagioli;D. Watson;F. Meeten;J. Smallwood;H. Critchley;C. Ottaviani
通讯作者：
Elena Makovac;S. Fagioli;D. Watson;F. Meeten;J. Smallwood;H. Critchley;C. Ottaviani
DOI：
10.1007/s12402-016-0208-3
发表时间：
2017-03
期刊：
Attention deficit and hyperactivity disorders
影响因子：
--
作者：
Fayyad J;Sampson NA;Hwang I;Adamowski T;Aguilar-Gaxiola S;Al-Hamzawi A;Andrade LH;Borges G;de Girolamo G;Florescu S;Gureje O;Haro JM;Hu C;Karam EG;Lee S;Navarro-Mateu F;O'Neill S;Pennell BE;Piazza M;Posada-Villa J;Ten Have M;Torres Y;Xavier M;Zaslavsky AM;Kessler RC;WHO World Mental Health Survey Collaborators
通讯作者：
WHO World Mental Health Survey Collaborators
影响因子：
8.8
作者：
Liu Y;Rodenkirch C;Moskowitz N;Schriver B;Wang Q
通讯作者：
Wang Q
ADHD 成人的非典型警戒状态控制：瞳孔测量研究
DOI：
--
发表时间：
2019
期刊：
影响因子：
--
作者：
Shirama;A.;Takeda;T.;Ohta;H.;& Toda;S.
通讯作者：
S.
注意力缺陷/多动障碍患者对不同精神努力要求的行为、生理和主观反应的初步研究
影响因子：
3.8
作者：
Gabry W. Mies;Pieter Moors;E. Sonuga;S. van der Oord;J. R. Wiersema;A. Scheres;J. Lemiere;M. Danckaerts
通讯作者：
M. Danckaerts