Dynamic Lateralization of Pupil Dilation Evoked by Locus Coeruleus Activation Results from Sympathetic, Not Parasympathetic, Contributions.
Dynamic Lateralization of Pupil Dilation Evoked by Locus Coeruleus Activation Results from Sympathetic, Not Parasympathetic, Contributions.
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DOI：
10.1016/j.celrep.2017.08.094
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发表时间：
2017-09-26
期刊：
影响因子：
8.8
通讯作者：
Wang Q
中科院分区：
文献类型：
--
作者：
Liu Y;Rodenkirch C;Moskowitz N;Schriver B;Wang Q
瞳孔大小由交感扩张肌和副交感括约肌共同控制。蓝斑（LC）的激活已被证明可以引起瞳孔扩张，但交感神经和副交感神经通路如何促进这种扩张仍不清楚。我们观察了轻麻醉大鼠LC激活引起的瞳孔扩张。单侧LC激活引起双侧但偏侧瞳孔扩张，即同侧瞳孔扩张明显大于对侧瞳孔扩张。手术阻断同侧而非对侧交感神经通路可显著降低侧化，提示侧化主要是交感神经的作用。此外，我们发现交感神经而非副交感神经的贡献与LC激活频率相关。总之，我们的研究结果揭示了交感神经和副交感神经通路对lc激活诱发的瞳孔扩张的频率依赖性贡献，并表明任务诱发的瞳孔扩张的侧化可能被用作自主神经张力的生物标志物。Liu等人的研究表明，单侧LC激活引起双侧但偏侧的瞳孔扩张。这种侧化依赖于LC激活的频率，这是交感神经而非副交感神经的作用。这提示了一种非侵入性技术，用于索引涉及自主神经系统紊乱的自主神经失衡。
Pupil size is collectively controlled by the sympathetic dilator and parasympathetic sphincter muscles. Locus coeruleus (LC) activation has been shown to evoke pupil dilation, yet how the sympathetic and parasympathetic pathways contribute to this dilation remains unknown. We examined pupil dilation elicited by LC activation in lightly anesthetized rats. Unilateral LC activation evoked bilateral, yet lateralized pupil dilation, i.e, the ipsilateral dilation was significantly larger than the contralateral dilation. Surgically blocking the ipsilateral, but not contralateral, sympathetic pathway significantly reduced lateralization, suggesting lateralization is mainly due to sympathetic contribution. Moreover, we found that sympathetic, but not parasympathetic, contribution is correlated with LC activation frequency. Together, our results unveiled the frequency-dependent contributions of the sympathetic and parasympathetic pathways to LC-activation-evoked pupil dilation, and suggest that lateralization in task-evoked pupil dilations may be used as a biomarker for autonomic tone. Liu et al. show that unilateral LC activation evokes bilateral yet lateralized pupil dilation. This lateralization is dependent upon the frequency of LC activation, which results from sympathetic but not parasympathetic contributions. This suggests a non-invasive technique for indexing autonomic imbalances in disorders involving the autonomic nervous system.
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