Association between intraoperative end-tidal carbon dioxide and postoperative nausea and vomiting in gynecologic laparoscopic surgery.
Association between intraoperative end-tidal carbon dioxide and postoperative nausea and vomiting in gynecologic laparoscopic surgery.
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妇科腹腔镜手术术中呼气末二氧化碳与术后恶心呕吐的关系。
DOI：
10.1038/s41598-022-10727-6
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发表时间：
2022-04-27
影响因子：
4.6
通讯作者：
Mizota, Toshiyuki
中科院分区：
文献类型：
--
作者：
Dong, Li;Takeda, Chikashi;Yamazaki, Hajime;Hamada, Miho;Hirotsu, Akiko;Yamamoto, Yosuke;Mizota, Toshiyuki
妇科腹腔镜手术术后恶心呕吐的发生率较高。研究表明，低术中潮气末二氧化碳（EtCO 2）与PONV的发生率增加有关，但研究结果并不一致。本研究调查了全麻下接受妇科腹腔镜手术的患者术中EtCO 2与PONV之间的相关性。这项回顾性队列研究涉及在京都大学医院全麻下接受妇科腹腔镜手术的患者。我们将低EtCO 2定义为平均EtCO 2 < 35 mmHg。多变量改良Poisson回归分析检查了术后两天内低EtCO 2和PONV与术后住院时间（PLOS）之间的关系。在739例患者中，120例（16%）EtCO 2较低，430例（58%）在术后2天内发生PONV。低EtCO 2与PONV发生率增加之间无实质性相关性（校正风险比：0.96; 95%置信区间[CI] 0.80-1.14; p = 0.658）。此外，低EtCO 2与PLOS延长之间没有实质性关联（PLOS的校正差异：0.13; 95% CI-1.00至1.28; p = 0.816）。术中低EtCO 2，特别是平均术中EtCO 2低于35 mmHg，与PONV发生率增加或PLOS延长无显著相关性。
Gynecologic laparoscopic surgery has a high incidence of postoperative nausea and vomiting (PONV). Studies suggest that low intraoperative end-tidal carbon dioxide (EtCO2) is associated with an increased incidence of PONV, but the results have not been consistent among studies. This study investigated the association between intraoperative EtCO2 and PONV in patients undergoing gynecologic laparoscopic surgeries under general anesthesia. This retrospective cohort study involved patients who underwent gynecologic laparoscopic surgeries under general anesthesia at Kyoto University Hospital. We defined low EtCO2 as a mean EtCO2 of < 35 mmHg. Multivariable modified Poisson regression analysis examined the association between low EtCO2 and PONV during postoperative two days and the postoperative length of hospital stay (PLOS). Of the 739 patients, 120 (16%) had low EtCO2, and 430 (58%) developed PONV during postoperative two days. There was no substantial association between low EtCO2 and increased incidence of PONV (adjusted risk ratio: 0.96; 95% confidence interval [CI] 0.80–1.14; p = 0.658). Furthermore, there was no substantial association between low EtCO2 and prolonged PLOS (adjusted difference in PLOS: 0.13; 95% CI − 1.00 to 1.28; p = 0.816). Intraoperative low EtCO2, specifically a mean intraoperative EtCO2 below 35 mmHg, was not substantially associated with either increased incidence of PONV or prolonged PLOS.
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影响因子：
1.4
作者：
Way M;Hill GE
通讯作者：
Hill GE
影响因子：
5.7
作者：
Macario, A;Weinger, M;Lee, M
通讯作者：
Lee, M
影响因子：
3.3
作者：
Guzman, JA;Kruse, JA
通讯作者：
Kruse, JA
影响因子：
5.7
作者：
Mizota, Toshiyuki;Dong, Li;Kai, Shinichi
通讯作者：
Kai, Shinichi
DOI：
10.1007/s12630-018-1249-1
发表时间：
2019-02-01
影响因子：
4.2
作者：
Akkermans, Annemarie;van Waes, Judith A. R.;Saager, Leif
通讯作者：
Saager, Leif