Prognostic and Immunological Role of Key Genes of Ferroptosis in Pan-Cancer.
Prognostic and Immunological Role of Key Genes of Ferroptosis in Pan-Cancer.
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铁死亡关键基因在泛癌中的预后和免疫学作用
DOI：
10.3389/fcell.2021.748925
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发表时间：
2021
影响因子：
5.5
通讯作者：
Bai J
中科院分区：
文献类型：
--
作者：
Shi ZZ;Tao H;Fan ZW;Song SJ;Bai J
溶质载体家族7成员11（SLC 7A 11）、谷胱甘肽过氧化物酶4（GPX 4）和凋亡诱导因子线粒体相关2（AIFM 2）是铁凋亡的关键调节因子。然而，这些基因在泛癌症中的表达模式和预后作用在很大程度上仍不清楚。通过使用TIMER、基因表达谱交互分析（GEPIA）、Oncomine和Kaplan-Meier数据库分析SLC 7A 11、GPX 4和AIFM 2的表达模式和预后作用以及这些基因的表达水平与泛癌中免疫浸润水平之间的关系。我们的研究结果表明，SLC 7A 11和GPX 4在结直肠癌中过表达，SLC 7A 11在肺癌中过表达。高水平的SLC 7A 11和AIFM 2分别与肾上腺皮质癌（ACC）中缩短的无病生存期和总生存期（OS）显著相关。SLC 7A 11、GPX 4和AIFM 2的高表达与急性髓系白血病患者OS缩短显著相关。在食管癌中，GPX 4表达与巨噬细胞和髓样树突状细胞浸润显著相关，AIFM 2表达与CD 4 + T细胞浸润显著相关。重要的是，GPX 4表达与ESCA和头颈部鳞状细胞癌（HNSC）中单核细胞标志物（CD 14和CD 115）和M2巨噬细胞标志物（VSIG 4和MS 4A 4A）的表达水平呈正相关。总之，SLC 7A 11、GPX 4和AIFM 2在许多类型的癌症中失调，并且是许多类型癌症的候选预后生物标志物，并且可用于评估肿瘤组织中免疫细胞的浸润。
Solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), and apoptosis inducing factor mitochondria associated 2 (AIFM2) are the key regulators in ferroptosis. However, the expression patterns and prognostic roles of these genes in pan-cancer are still largely unclear. The expression patterns and prognostic roles of SLC7A11, GPX4, and AIFM2 and the relationships between the expression levels of these genes and immune infiltration levels in pan-cancer were analyzed by using TIMER, gene expression profiling interactive analysis (GEPIA), Oncomine, and Kaplan–Meier databases. Our results showed that both SLC7A11 and GPX4 were overexpressed in colorectal cancer, and SLC7A11 was overexpressed in lung cancer. High levels of SLC7A11 and AIFM2 were significantly linked with the shortened disease-free survival and overall survival (OS) in adrenocortical carcinoma (ACC), respectively. And high expression of SLC7A11, GPX4, and AIFM2 were significantly correlated with the shortened OS of acute myeloid leukemia patients. In esophageal carcinoma (ESCA), GPX4 expression was significantly associated with the infiltration of macrophage and myeloid dendritic cell, and AIFM2 expression was significantly associated with the infiltration of CD4+ T cell. Importantly, GPX4 expression was positively correlated with the expression levels of monocyte markers (CD14 and CD115) and M2 macrophage markers (VSIG4 and MS4A4A) both in ESCA and in head and neck squamous cell carcinoma (HNSC). In summary, SLC7A11, GPX4, and AIFM2 are dysregulated in many types of cancers, and are candidate prognostic biomarkers for many types of cancers, and can be used to evaluate the infiltration of immune cells in tumor tissues.
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GEPIA：用于癌症和正常基因表达谱和交互式分析的网络服务器。
影响因子：
14.9
作者：
Tang Z;Li C;Kang B;Gao G;Li C;Zhang Z
通讯作者：
Zhang Z
影响因子：
3.3
作者：
Tian X;Li S;Ge G
通讯作者：
Ge G
影响因子：
10.1
作者：
Birsen R;Larrue C;Decroocq J;Johnson N;Guiraud N;Gotanegre M;Cantero-Aguilar L;Grignano E;Huynh T;Fontenay M;Kosmider O;Mayeux P;Chapuis N;Sarry JE;Tamburini J;Bouscary D
通讯作者：
Bouscary D
影响因子：
12.3
作者：
Li B;Severson E;Pignon JC;Zhao H;Li T;Novak J;Jiang P;Shen H;Aster JC;Rodig S;Signoretti S;Liu JS;Liu XS
通讯作者：
Liu XS
影响因子：
2
作者：
Fukuda, Masakatsu;Ogasawara, Yudai;Sakashita, Hideaki
通讯作者：
Sakashita, Hideaki