Two DNA repair gene polymorphisms on the risk of gastrointestinal cancers: a meta-analysis
Two DNA repair gene polymorphisms on the risk of gastrointestinal cancers: a meta-analysis
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两种 DNA 修复基因多态性与胃肠道癌症风险的荟萃分析
DOI：
10.1007/s13277-013-1320-z
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Li Liu
中科院分区：
文献类型：
--
作者：
Xiangquan Kong;Yamei Zheng;Jianxu Li;Li Liu
PARP-1和MGMT在DNA修复系统中起重要作用，因此与人类肿瘤发生有关。然而，研究最多的PARP-1 rs 1136410：T > C和MGMTrs 12917：C > T多态性与胃肠道（GI）癌风险之间的相关性报道结果不确定。因此，对23项已发表的病例对照研究进行了荟萃分析，以使用粗比值比（OR）和95%置信区间（CI）评估关联强度。总体而言，PARP-1 rs 1136410：T > C多态性的C等位基因与GI癌易感性增加显著相关（纯合子比较：OR = 1.43，95% CI 1.14-1.81;杂合子比较：OR = 1.18，95% CI 1.07-1.29;显性模型：OR = 1.23，95% CI 1.12-1.35;隐性模式：OR = 1.30，95% CI 1.04-1.62;等位基因比较：OR = 1.19，95% CI 1.07-1.32）。在亚组分析中，在亚洲人群、胃癌和高质量研究中发现了明显的相关性。对于MGMTrs 12917：C > T多态性，所有遗传模型总体上没有发现明显的关联。然而，在亚组分析中，我们发现T等位基因与杂合子（OR = 0.83，95% CI 0.70-0.97）和显性模型（OR = 0.84，95% CI 0.72-0.98）的结直肠癌风险降低显着相关。综上所述，PARP-1 rs 1136410：T > C多态性是GI癌的易感因素，而MGMTrs 12917：C > T多态性是结直肠癌的保护因素。大规模和精心设计的病例对照研究是必要的，以验证本荟萃分析中确定的风险。
PARP-1andMGMTplay an important role in the DNA repair system and therefore have been implicated in human carcinogenesis. However, the association between the most studiedPARP-1rs1136410: T > C andMGMTrs12917: C > T polymorphism and risk of gastrointestinal (GI) cancers was reported with inconclusive results. Accordingly, a meta-analysis of 23 published case–control studies was conducted to assess the strength of association using crude odds ratios (ORs) with 95 % confidence intervals (CIs). Overall, the C allele ofPARP-1rs1136410: T > C polymorphism was significantly associated with increased susceptibility of GI cancers (homozygote comparison: OR = 1.43, 95 % CI 1.14–1.81; heterozygote comparison: OR = 1.18, 95 % CI 1.07–1.29; dominant model: OR = 1.23, 95 % CI 1.12–1.35; recessive model: OR = 1.30, 95 % CI 1.04–1.62; allelic comparison: OR = 1.19, 95 % CI 1.07–1.32). In the subgroup analysis, still obvious associations were found in the Asian population, gastric cancer, and high-quality studies. ForMGMTrs12917: C > T polymorphism, no obvious associations were found for all genetic models overall. However, in the subgroup analysis, we found that the T allele was significantly associated with reduced colorectal cancer risk for heterozygote (OR = 0.83, 95 % CI 0.70–0.97) and dominant model (OR = 0.84, 95 % CI 0.72–0.98). In conclusion, this meta-analysis suggests that thePARP-1rs1136410: T > C polymorphism is a susceptibility factor for GI cancers, but the variant allele ofMGMTrs12917: C > T polymorphism appears to be a protective factor for colorectal cancer. Large-scale and well-designed case–control studies are necessary to validate the risk identified in the present meta-analysis.
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影响因子：
5.6
作者：
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通讯作者：
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DOI：
10.1891/9780826121646.0002
发表时间：
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期刊：
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影响因子：
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DOI：
10.1016/0021-9681(79)90031-6
发表时间：
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期刊：
Journal of Chronic Diseases
影响因子：
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作者：
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通讯作者：
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DOI：
10.1097/01.pgp.0000235064.93182.ec
发表时间：
2007-04-01
影响因子：
2.4
作者：
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通讯作者：
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