Virokines in the Pathogenesis of Cancer: Focus on Human Herpesvirus 8
Virokines in the Pathogenesis of Cancer: Focus on Human Herpesvirus 8
复制标题
Virokine 在癌症发病机制中的作用：聚焦人类疱疹病毒 8
DOI：
--
复制
发表时间：
2004
影响因子：
5.2
通讯作者：
Stefan Rose
中科院分区：
文献类型：
--
作者：
Mariam Klouche;Giuseppe Carruba;Luigi Castagnetta;Stefan Rose
摘要：在进化过程中，DNA病毒已经捕获了大量参与免疫识别和生长控制的细胞基因，这些基因对于病毒复制来说是不必要的。编码的病毒因子和病毒受体可以作为其细胞同源物的模拟物或拮抗剂，改变信号转导和细胞通讯，使病毒感染的细胞存活。人类疱疹病毒8型（HHV 8）是最近发现的人类致癌疱疹病毒。它与卡波西肉瘤和淋巴增生性疾病有关，如胸腔积液淋巴瘤和多中心Castleman病。HHV 8捕获了独特数量的细胞调节基因，这些基因重定向基因表达和细胞生长，阻止细胞凋亡和免疫识别，并干扰肿瘤抑制基因功能。HHV 8编码一种独特的病毒因子，病毒白细胞介素-6，这与HHV 8相关肿瘤的发病机制特别相关，因为它参与转化并介导自分泌和旁分泌促有丝分裂和促炎作用。病毒IL-6与人IL-6在信号转导的受体接合方面有根本性的不同，因此构成了理解人类和病毒细胞因子生物学方面的单一模型。我们概述了病毒因子在癌症中的作用，特别关注人类和病毒IL-6在HHV 8相关肿瘤病理生理学中的差异。
Abstract: During evolution, DNA viruses have captured a broad array of cellular genes involved in immune recognition and growth control that are nonessential for viral replication. The encoded virokines and viroceptors may act as mimetics or antagonists of their cellular homologues, altering signal transduction and cell communication towards survival of virus‐infected cells. Human herpesvirus type 8 (HHV8) is the most recently identified human oncogenic herpesvirus. It is associated with Kaposi's sarcoma and lymphoproliferative diseases, such as pleural effusion lymphomas and multicentric Castleman's disease. HHV8 has captured a unique number of cellular regulatory genes, which redirect gene expression and cell growth, prevent apoptosis and immune recognition, and interfere with tumor suppressor gene function. HHV8 encodes a unique virokine, viral interleukin‐6, which is particularly relevant for the pathogenesis of HHV8‐associated tumors, since it participates in transformation and mediates autocrine and paracrine mitogenic and proinflammatory effects. Viral IL‐6 differs fundamentally from human IL‐6 in receptor engagement for signal transduction and thus constitutes a singular model to understand the facets of human and viral cytokine biology. We provide an overview of the role of virokines in cancer, with a particular focus on the differences of human and viral IL‐6 in the pathophysiology of HHV8‐associated tumors.
登录
查看更多内容
人类疱疹病毒 8（卡波西肉瘤相关疱疹病毒）癌基因卡波辛 (ORF K12) 的表征。
DOI：
10.1016/s1386-6532(99)00081-5
发表时间：
2000
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
影响因子：
--
作者：
Muralidhar,S;Veytsmann,G;Chandran,B;Ablashi,D;Doniger,J;Rosenthal,LJ
通讯作者：
Rosenthal,LJ
DOI：
10.1073/pnas.93.25.14862
发表时间：
1996-12-10
影响因子：
11.1
作者：
Russo, JJ;Bohenzky, RA;Moore, PS
通讯作者：
Moore, PS
DOI：
10.1073/pnas.94.2.690
发表时间：
1997-01-21
影响因子：
11.1
作者：
Cheng, EHY;Nicholas, J;Hardwick, JM
通讯作者：
Hardwick, JM
影响因子：
56.9
作者：
Boshoff, C;Endo, Y;Weiss, RA
通讯作者：
Weiss, RA
影响因子：
32.4
作者：
Ishido, S;Choi, JK;Jung, JU
通讯作者：
Jung, JU