The role of 14-3-3 proteins in cell signalling pathways and virus infection.

The role of 14-3-3 proteins in cell signalling pathways and virus infection.
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14-3-3蛋白在细胞信号通路和病毒感染中的作用

DOI:
10.1111/jcmm.16490
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发表时间:
2021-05
影响因子:
5.3
通讯作者:
Xiao Y
Xiao Y
中科院分区:
医学2区
文献类型:
--
作者:
Liu J;Cao S;Ding G;Wang B;Li Y;Zhao Y;Shao Q;Feng J;Liu S;Qin L;Xiao Y

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14‐3‐3蛋白在从酵母到哺乳动物的物种中高度保守,并通过与携带磷酸化14‐3‐3结合基序的蛋白直接相互作用来调节许多信号通路。最近的研究表明,14‐3‐3蛋白也可以在病毒感染中发挥作用。本文综述了14‐3‐3蛋白在蛋白质转运、细胞周期调控、细胞凋亡、自噬等细胞信号转导途径中的生物学功能及其相关机制。本文还综述了最近关于14‐3‐3蛋白在病毒感染和先天免疫中的作用的研究结果。
14‐3‐3 proteins are highly conserved in species ranging from yeast to mammals and regulate numerous signalling pathways via direct interactions with proteins carrying phosphorylated 14‐3‐3–binding motifs. Recent studies have shown that 14‐3‐3 proteins can also play a role in viral infections. This review summarizes the biological functions of 14‐3‐3 proteins in protein trafficking, cell‐cycle control, apoptosis, autophagy and other cell signal transduction pathways, as well as the associated mechanisms. Recent findings regarding the role of 14‐3‐3 proteins in viral infection and innate immunity are also reviewed.
DOI: 10.1242/dev.156018
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