Nanocarriers for tracking and treating diseases.
Nanocarriers for tracking and treating diseases.
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DOI：
10.2174/0929867311320280007
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发表时间：
2013
影响因子：
4.1
通讯作者：
Dhar S
中科院分区：
文献类型：
--
作者：
Marrache S;Pathak RK;Darley KL;Choi JH;Zaver D;Kolishetti N;Dhar S
高效率的定点给药是当前制药领域面临的最大挑战。基于生物可降解聚合物的控释纳米颗粒平台可有益于针对无数重要人类疾病的治疗剂和造影剂的靶向递送。可生物降解的纳米颗粒，它可以被设计成负载多种药物与不同的物理化学性质，造影剂，和细胞或细胞内的成分靶向部分，已成为潜在的替代跟踪和治疗人类疾病。在这篇综述中，我们将重点介绍这些平台的设计和执行方面的当前进展，这些平台在诊断和治疗从癌症到阿尔茨海默氏症的各种疾病方面的潜在应用，我们将对它们可能的临床翻译的相关挑战进行批判性分析。
Site directed drug delivery with high efficacy is the biggest challenge in the area of current pharmaceuticals. Biodegradable polymer-based controlled release nanoparticle platforms could be beneficial for targeted delivery of therapeutics and contrast agents for a myriad of important human diseases. Biodegradable nanoparticles, which can be engineered to load multiple drugs with varied physicochemical properties, contrast agents, and cellular or intracellular component targeting moieties, have emerged as potential alternatives for tracking and treating human diseases. In this review, we will highlight the current advances in the design and execution of such platforms for their potential application in the diagnosis and treatment of variety of diseases ranging from cancer to Alzheimer’s and we will provide a critical analysis of the associated challenges for their possible clinical translation.
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影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
影响因子：
3.7
作者：
Doiron, Amber L.;Homan, Kimberly A.;Emelianov, Stanislav;Brannon-Peppas, Lisa
通讯作者：
Brannon-Peppas, Lisa
影响因子：
10.8
作者：
Brigger, I;Morizet, J;Vassal, G
通讯作者：
Vassal, G
影响因子：
14
作者：
Cheng, Jianjun;Teply, Benjamin A.;Farokhzad, Omid C.
通讯作者：
Farokhzad, Omid C.
DOI：
10.1073/pnas.1011379108
发表时间：
2011-02-01
影响因子：
11.1
作者：
Dhar, Shanta;Kolishetti, Nagesh;Farokhzad, Omid C.
通讯作者：
Farokhzad, Omid C.