Poly(lactic-co-glycolic) acid as a carrier for imaging contrast agents.
Poly(lactic-co-glycolic) acid as a carrier for imaging contrast agents.
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DOI：
10.1007/s11095-008-9786-x
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发表时间：
2009-03
影响因子：
3.7
通讯作者：
Brannon-Peppas, Lisa
中科院分区：
文献类型：
--
作者：
Doiron, Amber L.;Homan, Kimberly A.;Emelianov, Stanislav;Brannon-Peppas, Lisa
关键词：
随着未来分子水平治疗的纳米医学领域的不断拓宽，以PLGA为主要成分和载体的用于增强单模或多模成像的纳米和微粒子被创造出来。采用乳化技术将亲水性和疏水性显影造影剂包埋在PLGA颗粒中。通过将银还原到PLGA表面，在聚合物核周围形成一个银笼，进一步增强了这些PLGA颗粒的成像对比度特性。MRI造影剂Gd-DTPA和外源性染料罗丹明6G均被包裹在PLGA中，并分别显示出增强MR和荧光对比度的作用。围绕PLGA纳米颗粒构建的银纳米笼具有很强的近红外光吸收性能，使其成为适合光学成像策略(如光声成像)的造影剂。生物可降解聚合物PLGA是一种用途极其广泛的纳米和微载体，可用于多种成像造影剂，具有在分子水平上靶向疾病状态的可能性。
With the broadening field of nanomedicine poised for future molecular level therapeutics, nano-and microparticles intended for the augmentation of either single- or multimodal imaging are created with PLGA as the chief constituent and carrier. Emulsion techniques were used to encapsulate hydrophilic and hydrophobic imaging contrast agents in PLGA particles. The imaging contrast properties of these PLGA particles were further enhanced by reducing silver onto the PLGA surface, creating a silver cage around the polymeric core. The MRI contrast agent Gd-DTPA and the exogenous dye rhodamine 6G were both encapsulated in PLGA and shown to enhance MR and fluorescence contrast, respectively. The silver nanocage built around PLGA nanoparticles exhibited strong near infrared light absorbance properties, making it a suitable contrast agent for optical imaging strategies such as photoacoustic imaging. The biodegradable polymer PLGA is an extremely versatile nano- and micro-carrier for several imaging contrast agents with the possibility of targeting diseased states at a molecular level.
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影响因子：
3.9
作者：
Chaw, CS;Yang, YY;Phan, TT
通讯作者：
Phan, TT
影响因子：
2.5
作者：
Birnbaum, Duane T.;Kosmala, Jacqueline D.;Brannon-Peppas, Lisa
通讯作者：
Brannon-Peppas, Lisa
DOI：
10.1155/mbd.1994.467
发表时间：
1994
期刊：
Metal-based drugs
影响因子：
--
作者：
Clement JL;Jarrett PS
通讯作者：
Jarrett PS
影响因子：
4.8
作者：
Mulder, WJM;Strijkers, GJ;Nicolay, K
通讯作者：
Nicolay, K
影响因子：
14
作者：
Gosheger, G;Hardes, J;von Eiff, C
通讯作者：
von Eiff, C