Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents.
Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents.
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DOI：
10.2337/dc10-0284
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发表时间：
2010-08
期刊：
影响因子：
16.2
通讯作者：
Caprio S
中科院分区：
文献类型：
--
作者：
D'Adamo E;Cali AM;Weiss R;Santoro N;Pierpont B;Northrup V;Caprio S
我们评估了两组肥胖青少年中脂肪肝在胰岛素敏感性和β细胞功能改变中的作用，这两组青少年的肝脂肪含量（肝脂肪分数[HFF]）不同，但具有相似的腹内肌细胞内脂质含量（IMCL）和总体肥胖程度。我们研究了23名高HFF（HFF >5.5%）的肥胖青少年和20名低HFF（HFF <5.5%）的肥胖青少年，年龄、坦纳分期、BMI z评分、体脂百分比、内脏脂肪和IMCL相匹配。所有受试者均接受口服葡萄糖耐量试验和两步高胰岛素-正葡萄糖钳夹、磁共振成像和1H核磁共振，以分别评估腹部脂肪分布、HFF和IMCL。高HFF组显示出显著较低的全身胰岛素敏感性指数（P = 0.001）和胰岛素分泌估计值（P = 0.03）。两组之间的基线肝葡萄糖生成（EGP）率无差异。在低剂量胰岛素期间，高HFF组对EGP的抑制明显较低（P = 0.04）;在第二步期间没有观察到差异。基线脂肪酸、甘油浓度和甘油转换的钳夹抑制在两组之间没有差异。在第二步中，高HFF组的葡萄糖处置率显著较低（P = 0.01）。独立于内脏脂肪和IMCL的脂肪肝在肥胖青少年的胰岛素抵抗状态中起着核心作用。
We evaluated the role of fatty liver in the alteration of insulin sensitivity and β-cell function in two groups of obese adolescents, differing in hepatic fat content (hepatic fat fraction [HFF]) but with similar intrabdominal intramyocellular lipid content (IMCL) and overall degree of obesity. We studied 23 obese adolescents with high HFF (HFF >5.5%) and 20 obese adolescents with low HFF (HFF <5.5%), matched for age, Tanner stage, BMI z score, and percentages of body fat, visceral fat, and IMCL. All subjects underwent an oral glucose tolerance test and a two-step hyperinsulinemic-euglycemic clamp, magnetic resonance imaging and 1H nuclear magnetic resonance to assess abdominal fat distribution, HFF, and IMCL, respectively. The high HFF group showed significantly lower whole-body insulin sensitivity index (P = 0.001) and estimates of insulin secretion (P = 0.03). The baseline hepatic glucose production (EGP) rate was not different between the two groups. Suppression of EGP was significantly lower (P = 0.04) in the high HFF group during low-dose insulin; no differences were observed during the second step. Baseline fatty acids, glycerol concentrations, and clamp suppression of glycerol turnover did not differ between the groups. During the second step, the glucose disposal rate was significantly lower (P = 0.01) in the high HFF group. Fatty liver, independent of visceral fat and IMCL, plays a central role in the insulin-resistant state in obese adolescents.
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影响因子：
16.2
作者：
Perseghin G
通讯作者：
Perseghin G
影响因子：
168.9
作者：
Weiss, R;Dufour, S;Caprio, S
通讯作者：
Caprio, S
影响因子：
5.8
作者：
Seppälä-Lindroos, A;Vehkavaara, S;Yki-Järvinen, H
通讯作者：
Yki-Järvinen, H
影响因子：
13.5
作者：
Cali, Anna M. G.;De Oliveira, Ana Mayra;Kim, Hyeonjin;Chen, Shu;Reyes-Mugica, Miguel;Escalera, Sandra;Dziura, James;Taksali, Sara E.;Kursawe, Romy;Shaw, Melissa;Savoye, Mary;Pierpont, Bridget;Constable, R. Todd;Caprio, Sonia
通讯作者：
Caprio, Sonia
DOI：
10.1152/ajpendo.00444.2007
发表时间：
2007-12-01
影响因子：
5.1
作者：
Kotronen, Anna;Vehkavaara, Satu;Yki-Jarvinen, Hannele
通讯作者：
Yki-Jarvinen, Hannele