Quantitative comparison of PET and Bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization.
Quantitative comparison of PET and Bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization.
复制标题
PET和BREMSSTRAHLUNG SPECT的定量比较，用于成像肝放射栓塞后体内YTTrium-90微球分布。
DOI：
10.1371/journal.pone.0055742
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
de Jong HW
中科院分区：
文献类型：
--
作者：
Elschot M;Vermolen BJ;Lam MG;de Keizer B;van den Bosch MA;de Jong HW
After yttrium-90 (90Y) microsphere radioembolization (RE), evaluation of extrahepatic activity and liver dosimetry is typically performed on 90Y Bremsstrahlung SPECT images. Since these images demonstrate a low quantitative accuracy, 90Y PET has been suggested as an alternative. The aim of this study is to quantitatively compare SPECT and state-of-the-art PET on the ability to detect small accumulations of 90Y and on the accuracy of liver dosimetry. SPECT/CT and PET/CT phantom data were acquired using several acquisition and reconstruction protocols, including resolution recovery and Time-Of-Flight (TOF) PET. Image contrast and noise were compared using a torso-shaped phantom containing six hot spheres of various sizes. The ability to detect extra- and intrahepatic accumulations of activity was tested by quantitative evaluation of the visibility and unique detectability of the phantom hot spheres. Image-based dose estimates of the phantom were compared to the true dose. For clinical illustration, the SPECT and PET-based estimated liver dose distributions of five RE patients were compared. At equal noise level, PET showed higher contrast recovery coefficients than SPECT. The highest contrast recovery coefficients were obtained with TOF PET reconstruction including resolution recovery. All six spheres were consistently visible on SPECT and PET images, but PET was able to uniquely detect smaller spheres than SPECT. TOF PET-based estimates of the dose in the phantom spheres were more accurate than SPECT-based dose estimates, with underestimations ranging from 45% (10-mm sphere) to 11% (37-mm sphere) for PET, and 75% to 58% for SPECT, respectively. The differences between TOF PET and SPECT dose-estimates were supported by the patient data. In this study we quantitatively demonstrated that the image quality of state-of-the-art PET is superior over Bremsstrahlung SPECT for the assessment of the 90Y microsphere distribution after radioembolization.
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影响因子：
1.5
作者：
D'Arienzo, Marco;Chiaramida, Paola;Bagni, Oreste
通讯作者：
Bagni, Oreste
影响因子：
9.3
作者：
Gates, Vanessa L.;Esmail, Abdulredha A. H.;Salem, Riad
通讯作者：
Salem, Riad
影响因子：
9.3
作者：
Garin, Etienne;Lenoir, Laurence;Boucher, E.
通讯作者：
Boucher, E.
影响因子：
2.8
作者：
Knesaurek, Karin;Machac, Josef;Heiba, Sherif
通讯作者：
Heiba, Sherif
影响因子：
3.7
作者：
Elschot, Mattijs;Nijsen, Johannes Franciscus Wilhelmus;de Jong, Hugo Wilhelmus Antonius Maria
通讯作者：
de Jong, Hugo Wilhelmus Antonius Maria