Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation.
Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation.
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DOI：
10.1038/s41523-018-0071-9
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发表时间：
2018
影响因子：
5.9
通讯作者：
Molnár B
中科院分区：
文献类型：
--
作者：
Valcz G;Buzás EI;Szállási Z;Kalmár A;Krenács T;Tulassay Z;Igaz P;Molnár B
癌是由分层组织的不同细胞群（例如癌症干细胞和非干（块）癌细胞）组成的复杂结构。它们的遗传/表观遗传组成以及恶性细胞群与其基质成纤维细胞之间的动态相互作用是转移性肿瘤侵袭的重要决定因素。这些相互作用的重要介质是小的、膜封闭的细胞外囊泡，特别是外泌体。癌细胞和成纤维细胞衍生的外泌体都携带一组调节分子，包括蛋白质和不同种类的RNA，它们协同支持转移性肿瘤扩散。在这里，我们简要概述了癌症干细胞和外泌体介导的富含成纤维细胞的转移生态位形成之间的潜在联系，以讨论它们在促进乳腺癌模型中肿瘤生长和转移扩张中的作用。
Carcinomas are complex structures composed of hierarchically organized distinct cell populations such as cancer stem cells and non-stem (bulk) cancer cells. Their genetic/epigenetic makeup and the dynamic interplay between the malignant cell populations and their stromal fibroblasts are important determinants of metastatic tumor invasion. Important mediators of these interactions are the small, membrane-enclosed extracellular vesicles, in particular exosomes. Both cancer cell and fibroblast-derived exosomes carry a set of regulatory molecules, including proteins and different species of RNA, which cooperatively support metastatic tumor spread. Here, we briefly overview potential links between cancer stem cells and the exosome-mediated fibroblast-enriched metastatic niche formation to discuss their role in the promotion of tumor growth and metastatic expansion in breast carcinoma models.
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影响因子：
64.5
作者：
Boelens MC;Wu TJ;Nabet BY;Xu B;Qiu Y;Yoon T;Azzam DJ;Twyman-Saint Victor C;Wiemann BZ;Ishwaran H;Ter Brugge PJ;Jonkers J;Slingerland J;Minn AJ
通讯作者：
Minn AJ
影响因子：
7.4
作者：
Fillmore, Christine M.;Kuperwasser, Charlotte
通讯作者：
Kuperwasser, Charlotte
影响因子：
--
作者：
Gutkin A;Uziel O;Beery E;Nordenberg J;Pinchasi M;Goldvaser H;Henick S;Goldberg M;Lahav M
通讯作者：
Lahav M
影响因子：
7.3
作者：
Barros FM;Carneiro F;Machado JC;Melo SA
通讯作者：
Melo SA
影响因子：
5.2
作者：
Cho, Jung Ah;Park, Ho;Lee, Kyo Won
通讯作者：
Lee, Kyo Won